Adrienne Miller was born in 1972 in Columbus, Ohio. She lived in a small farming community surrounded by silos and cornfields until she was nine years old. At nine, her parents moved to a suburb of Akron, Ohio.
She moved to New York City, New York in the spring of 1994, a week before her college graduation. She worked at GQ, as an editorial assistant, then as an assistant editor. In 1997, she became the literary editor of Esquire, a position she held until leaving in 2005. In 2006, that position was filled by Tom Chiarella.
Her first novel, The Coast of Akron, was published by Farrar, Straus and Giroux in the summer of 2005.
During the fall semester of 2009, she took up a teaching position at the University of Pennsylvania's College of Arts and Sciences where she taught a writing seminar on Russian author Vladimir Nabokov and Swedish filmmaker Ingmar Bergman.