Early career

Sherman-Palladino became a staff writer on Roseanne during the show's third season in 1990. Among the storylines and episodes she wrote was an Emmy-nominated episode about birth control. She left the show after season six, in 1994, and worked on several other projects including the failed 1996 sitcom Love and Marriage, the 1997 sitcom Over the Top, and writing several scripts of the NBC sitcom Veronica's Closet.

Gilmore Girls

Sherman-Palladino is best known as the creator and executive producer of Gilmore Girls, an hour-long television dramedy that aired initially on The WB network, and concluded on its successor network, The CW. She and her husband wore many hats as the creative forces of the show, writing many of the episodes and also acting as producers, directors, and show runners for six of its seven years' run.

End of working relationship with Gilmore Girls

On April 20, 2006, it was announced that Amy Sherman-Palladino and her husband Daniel could not come to an agreement with The CW to continue their contracts. As a result, the Palladinos' involvement with Gilmore Girls came to an end. Writer and producer David S. Rosenthal replaced them.

The couple did an interview with TV Guide writer Michael Ausiello, where they went further into their reasons for leaving the show. The official statement was as follows: "Despite our best efforts to return and ensure the future of Gilmore Girls for years to come, we were unable to reach an agreement with the studio and are therefore leaving when our contracts expire at the end of this season. Our heartfelt thanks go out to our amazing cast, hard-working crew and loyal fans."

The Return of Jezebel James

On August 1, 2006, the Hollywood Reporter reported that the Fox Network had ordered a pilot of a new comedy project from Sherman-Palladino. The untitled comedy, which received a pilot commitment from the network, was about two sisters who come together after years apart, when one of the sisters agrees to carry the other's baby. Sherman-Palladino wrote, executive produced and directed the pilot.

In December 2006, at the Hollywood Radio & Television Society's Hitmakers luncheon, Palladino revealed the name of her new sitcom: The Return of Jezebel James. The series debuted on March 14, 2008 on FOX starring Parker Posey. The show was subsequently cancelled March 24, 2008 after only three episodes were aired.

Forthcoming HBO Project

On October 13, 2009, the Hollywood Reporter reported that Sherman-Palladino had been signed to write and executive produce an as yet untitled drama series for HBO. The series will "chronicle the complicated relationship between three adult sisters, all writers sharing the same upper east side apartment building, and their mother, a domineering literary lioness who reserves most of her affections for their ne'er-do-well brother."

Continued Work with the CW

The CW ordered a pilot created by Amy Sherman-Palladino and her executive producer husband Dan Palladino, tentatively known as 'The Wyoming Project' for consideration for the 2010-11 television season. The series was described as a family soap set on a horse farm in a small town in Midwest or Rockies. Entertainment Weekly described the series as "Gilmore Girls meets Little House on the Prairie". On the February 22, Sean Faris was tapped as the lead in the farm drama pilot, playing Gideon Thorpe. Entertainment Weekly also reported that Sherman-Palladino would be taking the directors chair on the pilot episode of 'Wyoming Project'. The CW did not pick up the pilot or order any episodes for the 2010-11 television season.