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This book is probably from the late 80s or 90s, and I think it's a Silhouette. The hero has "locked-in" syndrome. I can't remember what he had done before but now he lives in his parents house because they are responsible for his care. The heroine is a new physical therapist (I think or maybe she's an occupational therapist or something similar) that has been brought in to work with the hero. Later on, he comes out of the locked in state although he still needs a lot of therapy to get back to his old life (I'm not sure if he totally does or not).
I know--it's not a lot to go on.
I thought I had it for a moment, but after reading your full message I don't have it. Theresa Weir wrote a book in which the hero was somewhat agoraphobic but it's been so long since I read I can't be sure it's the same one you're looking for. Some help I am - I can't even remember the title. I'd have to check her website.