Cheiro was born in a village outside Dublin, Ireland. He took the name Count Louis Hamon (or Count Leigh de Hamong), claiming a noble ancestry that probably had no basis in truth.

As mentioned in his memoirs, Cheiro acquired his expertise in India. As a teenager, he traveled to the Bombay port of Apollo Bunder. There, he met his Guru, an Indian Brahmin, who took him to his village in the valley of the Konkan region of Maharashtra. After studying thoroughly for two years, he returned to London and started his career as a palmist.

Cheiro was reluctant to marry but was aware that he was destined to marry late in life. This did happen after a woman took care of him during a serious illness. A separate chapter is devoted on this matter in his memoirs.

Cheiro had a wide following of famous European and American clients during the late 19th and early 20th centuries. He read palms and told the fortunes of famous celebrities like Mark Twain, W. T. Stead, Sarah Bernhardt, Mata Hari, Oscar Wilde, Grover Cleveland, Thomas Edison, the Prince of Wales, General Kitchener, William Ewart Gladstone, and Joseph Chamberlain. He documented his sittings with these clients by asking them to sign a guest book he kept for the purpose, in which he encouraged them to comment on their experiences as subjects of his character analyses and predictions.

In his own autobiographical book, "Cheiro's Memoirs: The Reminiscences of a Society Palmist," he included accounts of his interviews with King Edward VII, William Gladstone, Charles Stewart Parnell, Henry Morton Stanley, Sarah Bernhardt, Oscar Wilde, Professor Max Muller, Blanche Roosevelt, the Comte de Paris, Joseph Chamberlain, Lord Russell of Killowen, Robert Ingersoll, Ella Wheeler Wilcox, Lillie Langtry, W.T. Stead (of Titanic fame), Richard Croker, Natalia Janotha, and other prominent people of his era.

The book "Titanic's Last Secrets" includes a detailed account of one of Cheiro's palm readings with William Pirrie, chairman of Harland and Wolf, builders of the Titanic. Cheiro predicted that he would soon be in a fight for his life, talking about the battle surrounding the Titanic sinking.

So popular was Cheiro as a "Society Palmist" that even those who were not believers in the occult had their hands read by him. The skeptical Mark Twain wrote in Cheiro's visitor's book:

Other mentions in the visitors book include:

"The study of people gifted with occult powers has interested me for several years. I have met and consulted scores.In almost ever respect I consider Cheiro the most highly gifted of all. He helps as well as astonishes."- Ella Wheeler Wilcox.

"You are wonderful. What more can I say"- Madame Nellie Melba.

After some years in London, and many world travels, Cheiro moved to America. He spent his final years in Hollywood, seeing as many as twenty clients a day and doing some screenwriting before his death there in 1936 following a heart attack. His widow, the Countess Lena Hamon, said her 70-year-old husband, who had been a friend and adviser to film actors late in life, and to European aristocracy and royalty in his early career, had predicted his own death to the hour the day before he died.

From Time Magazine of October 19, 1936:

Died. Count Louis Hamon ("Cheiro"), 69, celebrated oldtime palmist; after long illness; in Hollywood. Author of a book on palmistry at 13, he amassed $250,000 from rich female clients, owned an English-language newspaper in Paris, The American Register. On the night he died, said his nurse, the clock outside his room struck the hour of one thrice.

The occult books Cheiro wrote centered on fortune telling. Many of Cheiro's books on occultism and fortune telling are still in print today and are available in both English and foreign language editions.

In 2006, the University of Tampa Press issued a critical new edition of his fictional work, A Study of Destiny, as the second volume of the series Insistent Visions — a series dedicated to reprinting little-known or neglected works of supernatural fiction, science fiction, mysteries, or adventure stories from the 19th century.The new edition is edited with an introduction, afterword, and notes by Sean Donnelly.KOI HAR

Numerology

• Cheiro's Book of Numbers

Palmistry

• Cheiro's Language of the Hand (first self-published in 1894)
• Cheiro's Guide to the Hand
• You and Your Hand
• Cheiro's Palmistry for All
• The Cheiro Book of Fate and Fortune

Astrology

• Where were you Born?
• Cheiro's You and Your Star: The Book of the Zodiac

Others

• Cheiro's Book of World Predictions
• Cheiro's Memoirs: The Reminiscences of a Society Palmist
• Titanic's Last Secrets
• True Ghost Stories (attested tales of paranormal experiences)

Fiction

• A Study of Destiny(also published as The Hand of Fate, first released in 1898)