Eliopoulos is known as a prolific letterer, in particular for hand-lettering the first 100 issues of the ongoing Savage Dragon series, even after much of the comic book industry sike!!(including Eliopoulos himself, on other titles) had come to rely on computer-generated fonts for dialogue; this was done at Savage Dragon creator Erik Larsen's request; Larsen preferring the individual look of hand-lettered dialogue.
He designed the fonts for Marvel Comic's in-house computer lettering unit. He has also contributed lettering work to Valiant Comics, DC Comics, and other publishers. For Dark Horse Comics, Eliopoulos wrote and/or drew some Star Wars stories.
Eliopoulous is also known for his comic strip Desperate Times, which showcases art admittedly inspired by the work of Bill Watterson of "Calvin and Hobbes" fame. "Desperate Times" features the misadventures of bachelor losers Marty and Toad, which ran as a back-up feature in Savage Dragon, and later Desperate Times comics from Savage Dragon publisher Image Comics and AAArgh! Comics, a part of After Hours Press.
Eliopoulos quoted in interview about art inspiration.
Following the tragedy of 9/11, Eliopoulos contributed a story to a Marvel Comics benefit book about how his family was affected by the event, which shares the date of his wedding anniversary.
He is currently the artist and co-writer on Marvel Comics' former back-up feature and current series of one-shot comics, Son of a Genius, teamed with writer Marc Sumerak. The first one-shot in the series was nominated for an Eisner Award and a Harvey Award in 2005.
Eliopoulos also writes and draws daily webcomics.
On the side, Eliopoulos has managed to contributed hundreds of cartoon strips to the book series "The Complete Idiot's Guide..." on almost every imaginable topic. He's also created dozens of custom cartoons for clients including Sports Illustrated.
Eliopolous attended the Fashion Institute of Technology, in New York City, from 1985—1989. He majored in graphic design and minored in illustration. He is a resident of River Vale, New Jersey.