Weston was born in January, 1969 in Rinteln, Germany, and lived in various countries as a child. His career began when he was apprenticed for a year to work with Don Lawrence, by the end of which he had secured paid work on the major British strip Judge Dredd.

He worked with writer John Smith on the ten-part Indigo Prime story, "Killing Time" in which characters battled Jack the Ripper aboard a time travelling train.

Weston's work in America began with on Swamp Thing during Mark Millar's time as scriptwriter. He has since gone on to be published in The Invisibles, Starman, JSA, Lucifer, and The Authority.

He has also worked on The Filth and Ministry of Space. The former a creator-owned written by Grant Morrison, the latter a "what if?" limited series written by Warren Ellis which saw Britain winning the Space Race.

Most recently he has provided the art for Fantastic Four: First Family.

Weston is currently illustrating The Twelve a twelve-issue limited series written J. Michael Straczynski. The series will involve a team formed from Timely Comics characters including The Witness, The Black Widow and Elektro.

Since 2005 Weston has written a number of stories that he has also drawn, including a number of one-offs for 2000 AD and The Twelve: Spearhead a prequel one-shot.

He has also worked on the film Book of Eli with Denzel Washington. He is drawing the story-boards for the film.

Comics work includes:

• Judge Dredd:
• "A Night at the Circus" (with John Wagner, in 2000 AD #596, 1988)
• "Worms" (with Alan Grant, in 2000 AD #598, 1988)
• "Accident Prone" (with Alan Grantr, in 2000 AD #602, 1988)
• "Tiger, Tiger" (with Alan Grant, in 2000 AD #607, 1988)
• "Crazy Barry, Little Mo" (with John Wagner, in 2000 AD #615—618, 1989)
• "The Great Little U-Front Disaster" (with John Wagner, in 2000 AD #641, 1989)
• "The Vidders" (with Garth Ennis, in 2000 AD #749, 1991)
• "To Thing With Love" (with John Wagner, in 2000 AD #956, 1995)
• "Rest Stop" (with Gordon Rennie, in 2000 AD #1194, 2000)
• "Six" (with John Wagner, in Judge Dredd Megazine #221-222, 2004)

• Tharg's Future Shocks:
• "Amanda" (with Jim Campbell, in 2000 AD #623, 1989)
• "House of the Future" (with Chris Gormley, in 2000 AD #637, 1989)
• "The Green Pedestrian Palm" (script and art, in 2000 AD Prog 2010, 2009)

• Indigo Prime (with John Smith):
• The Complete Indigo Prime (168 pages, Rebellion, 2005 ISBN 1-904265-42-1) collects:
• "Indigo Prime" (in 2000 AD #678, 1989)
• "Winwood and Cord" (in 2000 AD #680—681, 1990)
• "Fegredo and Brecht" (in 2000 AD #682, 1990)
• "Killing Time" (in 2000 AD #735—744, 1991)
• "Requiem" (illustrated text story, in 2000AD Winter Special 1990)

• Rogue Trooper (Friday):
• "Scavenger of Souls" (with Michael Fleisher, in 2000 AD #873—880, 1994)
• "Hill 392" (with Steve White, in Poster Prog Rogue Trooper #1, 1994)
• "G.I. Blues" (with Mark Millar, in 2000 AD #901—903, 1994)

• Robo-Hunter: "Something for the Weekend, Sir?" (with John Smith, in 2000 AD Sci-Fi Special 1992, June 1992)

• Canon Fodder:
• "Canon Fodder" (with Mark Millar, in 2000 AD #861—867, 1993)
• "Dark Matter" (with Kek-W, in 2000 AD #981—987, 1995)

• Swamp Thing #153 (pencils, with Mark Millar, Vertigo, April 1995)

• The Invisibles (with Grant Morrison, Vertigo):
• The Invisibles vol. 1 #10 (July 1995)
• The Invisibles vol. 2 #9, 14—17, 19—22 (October 1997, April—August 1998, October 1998 — February 1999)
• The Invisibles vol. 3 #3 (April 2000)

• Vector 13: "Case One: Side Step" (with Dan Abnett, in 2000 AD #1062, 1997)
• Nikolai Dante: "Russia's Greatest Love Machine" (with Robbie Morrison, in 2000 AD #1066, 1997, collected in Nikolai Dante: The Romanov Dynasty Pt. 2, 192 pages, November 2004, ISBN 1-904265-20-0)
• Time Breakers (with Rachel Pollack, 5-issue limited series, Helix, 1997)
• Star Spangled Comics #1 (with Geoff Johns, DC Comics, May 1999, collected in JSA: The Justice Society Returns, 256 pages, DC, 2003, ISBN 1-4012-0090-7)
• Starman #55: "Taxi Cab Confessions" (pencils, with writers David S. Goyer and James Dale Robinson, with inks by Keith Champagne, DC Comics, July 1999, collected in Stars My Destination, 135 pages, 2004, Titan, ISBN 1-84023-740-6, DC, ISBN 1-4012-0011-7)
• Downlode Tales: "City on Fire" (with Dan Abnett, in 2000 AD #1155—1160, August—September 1999)
• Pulp Sci-Fi: "Feast of Skin" (with John Smith, in 2000 AD #1163, September 1999)
• Lucifer #1—3: "A Six-Card Spread" (with Mike Carey, Vertigo, June—August 2000, collected in Devil In The Gateway, 160 pages, 2001, Titan, ISBN 1-84023-299-4, DC, ISBN 1-56389-733-4)
• The Authority #18—19 (with Mark Millar, Wildstorm, 2000, collected in Earth Inferno and Other Stories, 192 pages, 2002, Titan, ISBN 1-84023-371-0, DC, ISBN 1-56389-854-3)
• Ministry of Space (with Warren Ellis, 3-issue mini-series, Image Comics, 2001, tpb, softcover ,March 2005, Image, ISBN 1-58240-423-2, Titan, ISBN 1-84023-924-7 and hardcover Image, March 2005, ISBN 1-58240-424-0)
• War Story: "Johann's Tiger"' (pencils, with Garth Ennis and inks by Gary Erskine, Vertigo, standalone one shot, 2001, collected in tpb War Stories: Volume 1, 2004, ISBN 1-84023-912-3)
• The Filth (pencils, with Grant Morrison and inks by Gray Erskine, 13-issue limited series, Vertigo, August 2002 - October 2003, tpb, 320 pages, 2004, Titan, ISBN 1840237392, DC, ISBN 1-4012-0013-3)
• Whatever Happened To?: "Tweak" (with Pat Mills, in Judge Dredd Megazine #214, 2004)
• "Heinrich Manoeuvre's H.e.a.d Trip!" (script and art, in Event Horizon, Mam Tor Publishing. May 2005, ISBN 0-9549998-0-0)
• Fantastic Four: First Family (pencils, with Joe Casey, and inks by Gary Erskine, 6-issue mini-series, Marvel Comics, 2006, tpb, 144 pages, November 2006, Marvel, ISBN 0-7851-1703-2)

• The Twelve (with J. Michael Straczynski, 12-issue limited series, Marvel Comics, 2008 - ongoing) collected as:
• Volume 1 (collects The Twelve #1-6, 144 pages, premiere hardcover, October 2008, ISBN 0-7851-3372-0)

• "The Little Guy" (with Mother, in Four Feet From a Rat, Mam Tor Publishing, given away in Time Out, March 19, 2008).
• Tharg's Terror Tales: "Counts as one choice" (script and art, in 2000 AD #1645, 2009)
• The Twelve: Spearhead (script and art, with some inks by Gary Erskine, one-shot, Marvel Comics, May 2010)

Interviews

• Chris Weston Interview, 2000ADReview, March 4, 2003
• Chris Weston: The Interview by Adriano Barone, Drive Magazine, March 20, 2004