Vachon is gay and has a daughter, Cook. Her partner is artist Marlene McCarty. Vachon recovered from breast cancer and chemotherapy in 2009.

Christine, along with partner Pamela Koffler, runs Killer Films. Killer celebrated its 10th anniversary in 2005 and was honored with a retrospective at the Museum of Modern Art.

Recent Killer releases include Todd Haynes's I'm Not There, starring Christian Bale, Cate Blanchett, Richard Gere, Heath Ledger, Charlotte Gainsbourg, Julianne Moore, and Michelle Williams. Cate Blanchett received both Academy Award and SAG Award nominations for Best Supporting Actress, and the film was also nominated for 4 Independent Spirit Awards, notching a Best Supporting Actress win for Cate Blanchett.

Killer’s releases for 2008 include Savage Grace, directed by Tom Kalin (Swoon) and starring Julianne Moore; An American Crime, starring Catherine Keener and Ellen Page, directed by Tommy O'Haver: Then She Found Me, the directorial debut of Helen Hunt, starring herself, Bette Midler, Colin Firth and Matthew Broderick.

Christine's new book, "A KILLER LIFE: HOW AN INDEPENDENT FILM PRODUCER SURVIVES DEAL AND DISASTERS IN HOLLYWOOD AND BEYOND" was published in September 2006 by Simon and Schuster. Her first book, "SHOOTING TO KILL" was published in the fall of 1998 by Avon, and was a Los Angeles Times bestseller.

Director's name in brackets after film title.

• 1991: Poison (Todd Haynes)
• 1992: Swoon (Tom Kalin)
• 1994: Postcards from America (Steve McLean)
• 1994: Go Fish (Rose Troche) (as executive producer)
• 1995: Stonewall (Nigel Finch)
• 1995: Safe (Todd Haynes)
• 1995: Kids (Larry Clark)
• 1996: I Shot Andy Warhol (Mary Harron)
• 1997: Office Killer (Cindy Sherman)
• 1997: Kiss Me, Guido (Tony Vitale)
• 1998: Happiness (Todd Solondz)
• 1998: Velvet Goldmine (Todd Haynes)
• 1999: Boys Don't Cry (Kimberly Peirce)
• 1999: I'm Losing You (Bruce Wagner)
• 2000: Crime and Punishment in Suburbia (Rob Schmidt)
• 2001: Hedwig and the Angry Inch (John Cameron Mitchell)
• 2001: The Contenders (Daniel Minaham)
• 2001: Women in Film (Bruce Wagner)
• 2001: Chelsea Walls (Ethan Hawke)
• 2001: Storytelling (Todd Solondz)
• 2002: One Hour Photo (Mark Romanek)
• 2001: The Grey Zone (Tim Blake Nelson)
• 2001: The Safety of Objects (Rose Troche)
• 2002: Far from Heaven (Todd Haynes)
• 2003: Party Monster (Fenton Bailey and Randy Barbato)
• 2003: Camp (Todd Graff)
• 2003: The Company (Robert Altman)
• 2004: A Home at the End of the World (Michael Mayer)
• 2004: A Dirty Shame (John Waters)
• 2006: The Notorious Bettie Page (Mary Harron)
• 2006: Mrs. Harris (Phyllis Nagy)
• 2006: Infamous (Douglas McGrath)
• 2007: This American Life (Ira Glass)
• 2007: An American Crime (Tommy O'Haver)
• 2007: I'm Not There (Todd Haynes)
• 2008: Savage Grace (Tom Kalin)
• 2008: Then She Found Me (Helen Hunt)
• 2008: Gigantic (Matt Aselton)