Wallace was born in Birmingham, Alabama. He has three sisters. He attended Emory University and University of North Carolina, Chapel Hill, studying English and philosophy. His first job was at a vet, cleaning cages and squeezing anal glands. He did not graduate from college until May 2008, instead taking a job with a trading company in Nagoya, Japan. He currently lives in Chapel Hill with his wife and son.
Wallace states, of his childhood, that "I was completely average in every way. My childhood was the most uneventful part of my life, I think." He reports, however, that there was friction within his family, as in an interview he states:
"My father wanted me to work with him in his company, an import/export firm, and to that end I lived in Japan for a couple of years. But it didn’t work out. It didn’t make me happy and the truth is I wasn’t that good at it. I wouldn’t have been a good businessman. I tried. So I quit — or, if he were alive and you could ask him, fired — and started writing. He wasn’t for it but then it’s hard to support a child in an endeavor for which he has shown absolutely no promise. My mother loved the idea of it because being a writer is such a romantic idea and because it hurt my father, and if he was hurt she was happy."
After returning to Chapel Hill, North Carolina, Wallace worked for thirteen years in a bookstore and as an illustrator, where he designed "whimsical greeting cards and refrigerator magnets." A running motif in his works are glass eyes; Wallace has stated in numerous interviews (including the one published in the back of the paperback edition of
Big Fish) that he collects glass eyes. He continued to live in Chapel Hill with his wife, Laura, a social worker, and their son, Henry.
Of his political beliefs, Wallace has stated, "It is fair to say that I’m left of center. Far left." Wallace claims he is an agnostic in terms of religious beliefs, stating:
"I think a lot of people default to Jesus when something inexplicable happens. I write things I didn’t know I was capable of writing, and sometimes that feels like magic. It isn’t; it’s just me. A similar thing happens when a tornado blows someone’s house away, but their cat is found unscathed in an oak tree: God must have been looking out for Pooky. We’re hard-wired to do this, I think, because we’ve been doing it since the beginning."