Hine has been working in comics since the early 1980s. For Crisis he drew the series Sticky Fingers (written by Myra Hancock) in 1989, and wrote and drew a number of short pieces in 1990 and 1991. For 2000 AD he drew Tao De Moto in 1991 (again written by Hancock) and wrote and drew the futuristic police series Mambo from 1994 to 1996.

He wrote and drew the black and white horror comic Strange Embrace, originally published as a mini-series by Atomeka Press in 1993, and later as a collected graphic novel by Active Images in the U.S., reprinted again as a color series by Image Comics.

Hine is currently best known as a writer on Marvel Comics titles, like The 198 and X-Men. One of his most recent projects there was Silent War a six-issue mini-series featuring the Inhumans with art by Frazer Irving. Hine has also written a number of What if? stories which look at alternate outcomes to stories like Annihilation and Deadly Genesis.

He was also the writer of Spawn for Image comics from issues # 151 to # 184 ., as well as writing his own manga series Poison Candy for Tokyopop and the Two-Face issue of The Joker's Asylum for DC. He will also be writing four issues of The Brave and the Bold with artist Doug Braithwaite, before J. Michael Straczynski starts his run on the title and he wrote the Deathstroke one-shot, which was part of the Faces of Evil series which deals with the aftermath of Final Crisis.. He recently wrote the Arkham Asylum one-shot for the Batman Battle for the Cowl event. His one shot lead to a mini series called "Arkham Reborn", the events lead into David Hine taking over Detective Comics continuing the story.

David also has another comic forthcoming from indie publisher, Radical Comics, The Federal Vampire and Zombie Agency, he has the book co-written with Roy Allan Martinez. and, from Image Comics, The Bulletproof Coffin with artist Shaky Kane.