Denis Diderot was born in the eastern French city of Langres and commenced his formal education in the Lycée Louis le Grand. In 1732, he earned a master of arts degree in philosophy. He abandoned the idea of entering the clergy and decided instead to study law. His study of law was short-lived; in 1734, Diderot decided instead to become a writer. Because of his refusal to enter one of the learned professions, he was disowned by his father, and for the next ten years he lived a rather bohemian existence.

In 1742, he befriended Rousseau. Then in 1743, he further alienated his father by marrying Antoinette Champion, a devout Roman Catholic. The match was considered inappropriate due to Champion's low social status, poor education, fatherless status, lack of a dowry, and—at thirty-two—being four years his senior. The marriage produced one surviving child, a girl. Her name was Angélique, after both Diderot's dead mother and sister. The death of his sister, a nun, from overwork in the convent may have affected Diderot's opinion of religion. She is assumed to have been the inspiration for his novel about a nun, La Religieuse, in which he depicts a woman who is forced to enter a monastery, and suffers at the hands of the other nuns in the community.

He had affairs with the writer Madame Puisieux and with Sophie Volland. His letters to Sophie Volland contain some of the most vivid of all the insights that we have of the daily life of the philosophic circle of Paris during this time period.

Though his work was broad and rigorous, it did not bring him riches. He secured none of the posts that were occasionally given to needy men of letters; he could not even obtain the bare official recognition of merit which was implied by being chosen a member of the Académie française. When the time came for him to provide a dowry for his daughter, he saw no alternative than to sell his library. When Catherine II of Russia heard of his financial troubles she commissioned an agent in Paris to buy the library. She then requested that the philosopher retain the books in Paris until she required them, and act as her librarian with a yearly salary. In 1773 and 1774, Diderot spent some months at the empress's court in Saint Petersburg.

Diderot died of gastro-intestinal problems in Paris on July 31, 1784, and was buried in the city's Église Saint-Roch. His heirs sent his vast library to Catherine II, who had it deposited at the National Library of Russia.

Diderot's earliest works included a translation of Temple Stanyan's History of Greece (1743); with two colleagues, François-Vincent Toussaint and Marc-Antoine Eidous, he produced a translation of Robert James's Medicinal Dictionary (1746—1748); at about the same time he published a free rendering of Shaftesbury's Inquiry Concerning Virtue and Merit (1745), with some original notes of his own. In 1746, he wrote his first original work: the Pensées philosophiques, and he added to this a short complementary essay on the sufficiency of natural religion. He then composed a volume of bawdy stories, Les bijoux indiscrets (1748); in later years he repented this work.In 1747, he wrote the Promenade du sceptique, an allegory pointing first at the extravagances of Catholicism; second, at the vanity of the pleasures of the world which is the rival of the church; and third, at the desperate and unfathomable uncertainty of the philosophy which professes to be so high above both church and world.

Diderot's celebrated Lettre sur les aveugles à l'usage de ceux qui voient ("Letter on the Blind") (1749), introduced him to the world as a daringly original thinker. The subject is a discussion of the interrelation between man's reason and the knowledge acquired through perception (the five senses). The title, "Letter on the Blind For the Use of Those Who See" also evoked some ironic doubt about who exactly were "the blind" under discussion. In the essay, a blind English mathematician named Saunderson argues that since knowledge derives from the senses, then mathematics is the only form of knowledge that both he and a sighted person can agree about. It is suggested that the blind could be taught to read through their sense of touch (a later essay, Lettre sur les sourds et muets, considered the case of a similar deprivation in the deaf and mute). What makes the Lettre sur les aveugles so remarkable, however, is its distinct, if undeveloped, presentation of the theory of variation and natural selection.

This powerful essay ... revolves around a remarkable deathbed scene in which a dying blind philosopher, Saunderson, rejects the arguments of a providential God during his last hours. Saunderson's arguments are those of a Neo-Spinozist, Naturalist, and Fatalist, using a sophisticated notion of the self-generation and natural evolution of species without Creation or supernatural intervention. The notion of "thinking matter" is upheld and the "argument from design" discarded ... as hollow and unconvincing. The work appeared anonymously ... and was vigorously suppressed by the authorities. Diderot, who had been under police surveillance since 1747, was swiftly identified as the author ... and was imprisoned for some months at Vincennes, where he was visited almost daily by Rousseau, at the time his closest and most assiduous ally.

After signing a letter of submission and promising never to write anything prejudicial against religion again (with the result that his most controversial works were henceforth published only after his death), Diderot was released from the dungeons of the Vincennes fortress after three months. In collaboration with d'Alembert, he subsequently embarked on his greatest project, The Encyclopédie, ou dictionnaire raisonné des sciences, des arts et des métiers.

André Le Breton, a bookseller and printer, approached Diderot with a project for the publication of a translation of Ephraim Chambers' Cyclopaedia, or Universal Dictionary of Arts and Sciences into French, first undertaken by the Englishman John Mills, and followed by the German Gottfried Sellius. Diderot accepted the proposal. During this translation his creative mind and astute vision transformed the work. Instead of a mere reproduction of the Cyclopaedia, he persuaded Le Breton to enter upon a new work, which would collect all the active writers, ideas, and knowledge that were moving the cultivated class of the Republic of Letters to its depths but were comparatively ineffectual due to their dispersion. His enthusiasm for the project was transmitted to the publishers; they collected a sufficient capital for a more vast enterprise than they had first planned. Jean le Rond d'Alembert was persuaded to become Diderot's colleague; the requisite permission was procured from the government.

In 1750 an elaborate prospectus announced the project to a delighted public, and in 1751 the first volume was published. This work was very unorthodox and had many forward-thinking ideas for the time. Diderot stated within this work, "An encyclopedia ought to make good the failure to execute such a project hitherto, and should encompass not only the fields already covered by the academies, but each and every branch of human knowledge." Upon encompassing every branch of knowledge this will give, "the power to change men's common way of thinking." This idea was profound and intriguing, as it was one of the first works during the Enlightenment. Diderot wanted to give all people the ability to further their knowledge and, in a sense, allow every person to have any knowledge they sought of the world. The work, implementing not only the expertise of scholars and Academies in their respective fields but that of the common men in their proficiencies in their trades, sought to bring together all knowledge of the time and condense this information for all to use. These people would amalgamate and work under a society to perform such a project. They would work alone to shed societal conformities, and build a multitude of information on a desired subject with varying view points, methods, or philosophies. He emphasized the vast abundance of knowledge held within each subject with intricacies and details to provide the greatest amount of knowledge to be gained from the subject. All people would benefit from these insights into different subjects as a means of betterment; bettering society as a whole and individuals alike.

However, Diderot's work was plagued by controversy from the beginning; the project was suspended by the courts in 1752. Just as the second volume was completed accusations arose, regarding seditious content, concerning the editors entries on religion and natural law. Diderot was detained and his house was searched for manuscripts for subsequent articles. But the search proved fruitless as no manuscripts could be found. They were hidden in the house of an unlikely confederate—Chretien de Lamoignon Malesherbes, the very official who ordered the search. Although Malesherbis was a staunch absolutist-loyal to the monarchy, he was sympathetic to the literary project. Along with his support, and that of other well-placed influential confederates, the project resumed. Diderot returned to his efforts only to be constantly embroiled in controversy.

These twenty years were to Diderot not merely only a time of incessant drudgery, but harassing persecution and desertion of friends. The ecclesiastical party detested the Encyclopédie, in which they saw a rising stronghold for their philosophic enemies. By 1757 they could endure it no longer. The subscribers had grown from 2,000 to 4,000, a measure of the growth of the work in popular influence and power. The Encyclopédie threatened the governing social classes of France (aristocracy) because it took for granted the justice of religious tolerance, freedom of thought, and the value of science and industry. It asserted the doctrine that the main concern of the nation's government ought to be the nation's common people. It was believed that the Encyclopédie was the work of an organized band of conspirators against society, and that the dangerous ideas they held were made truly formidable by their open publication. In 1759, the Encyclopédie was formally suppressed. The decree did not stop the work, which went on, but its difficulties increased by the necessity of being clandestine. Jean le Rond d'Alembert withdrew from the enterprise and other powerful colleagues, including Anne Robert Jacques Turgot, Baron de Laune, declined to contribute further to a book which had acquired a bad reputation.

Diderot was left to finish the task as best he could. He wrote several hundred articles, some very slight, but many of them laborious, comprehensive, and long. He damaged his eyesight correcting proofs and editing the manuscripts of less competent contributors. He spent his days at workshops, mastering manufacturing processes, and his nights writing what he had learned during the day. He was incessantly harassed by threats of police raids. The last copies of the first volume were issued in 1765. At the last moment, when his immense work was drawing to an end, he encountered a crowning mortification: he discovered that the bookseller, fearing the government's displeasure, had struck out from the proof sheets, after they had left Diderot's hands, all passages that he considered too dangerous. The monument to which Diderot had given the labor of twenty long and oppressive years was irreparably mutilated and defaced. It was 12 years, in 1772, before the subscribers received the final 27 folio volumes of the Encyclopédie, ou dictionnaire raisonné des sciences, des arts et des métiers since the first volume had been published.

Although the Encyclopédie was Diderot's monumental piece, he was the author of many other works that sowed nearly every field of intellectual interest with new and creative ideas. He wrote sentimental plays, Le Fils naturel (1757) and Le Père de famille (1758), accompanying them with essays on theatrical theory and practice, including Les Entretiens sur Le Fils naturel (Conversations on Le Fils naturel), in which he announced the principles of a new drama...the serious, domestic, bourgeois drama of real life, in opposition to the stilted conventions of the classical French stage. His art criticism was also highly influential. Diderot's Essais sur la peinture was described by Johann Wolfgang von Goethe, as "a magnificent work, which speaks even more helpfully to the poet than to the painter, though to the painter too it is as a blazing torch."

Diderot's most intimate friend was the philologist Friedrich Melchior Grimm. They were brought together by their friend in common at that time, Jean-Jacques Rousseau. Grimm wrote newsletters to various high personages in Germany, reporting the happenings of art and literature in Paris, then the intellectual capital of Europe. Diderot helped Grimm between 1759 and 1779, by writing an account of the annual exhibitions of paintings in the Paris Salon. These reports are highly readable pieces of art criticism. According to Charles Augustin Sainte-Beuve, they initiated the French into a new way of laughing, and introduced people to the mystery and purport of colour by ideas. "Before Diderot," Anne Louise Germaine de Staël wrote, "I had never seen anything in pictures except dull and lifeless colours; it was his imagination that gave them relief and life, and it is almost a new sense for which I am indebted to his genius." Jean-Baptiste Greuze was Diderot's favorite contemporary artist. Greuze's most characteristic pictures were the rendering in colour of the same sentiments of domestic virtue and the pathos of common life, which Diderot had attempted to represent upon the stage.

Diderot was above all things interested in the life of individuals. He did not care about the abstract life of the race, but the incidents of individual character, the fortunes of a particular family, the relations of real and concrete motives in this or that special case. He was delighted with the enthusiasm of a born casuist in curious puzzles of right and wrong, and in devising a conflict between the generalities of ethics and the conditions of an ingeniously contrived practical dilemma. Diderot's interest expressed itself in didactic and sympathetic form. However, in two of his most remarkable pieces, this interest is not sympathetic, but ironic. Jacques le fataliste (written in 1773, but not published until 1792 in German and 1796 in French) is similar to Tristram Shandy and The Sentimental Journey. His dialogue Le Neveu de Rameau (Rameau's Nephew) is a "farce-tragedy" reminiscent of the Satires of Horace. A favorite classical author of Diderot's, Horace's words Vertumnis, quotquot sunt, natus iniquis are quoted at the top of the Nephew. Diderot's intention in writing the dialogue is disputed; whether it is merely a satire on contemporary manners, or a reduction of the theory of self-interest to an absurdity, or the application of irony to the ethics of ordinary convention, or a mere setting for a discussion about music, or a vigorous dramatic sketch of a parasite and a human original. Whatever its intent, it is a remarkable conversation, representing an era of that held the art of conversation in the highest regard.

The writing and publication history of the Nephew is likewise a bit mysterious. Diderot never saw the work through to publication during his lifetime, but there is every indication it was of continual interest to him. Though the original draft was written in 1761, he made additions to it year after year until his death twenty-three years later. Goethe's translation (1805) was the first introduction of Le Neveu de Rameau to the European public. After executing it, he gave back the original French manuscript to Friedrich Schiller, from whom he had it. No authentic French copy of it appeared until the writer had been dead for forty years (1823). Diderot's miscellaneous pieces range from a graceful trifle like the Regrets sur ma vieille robe de chambre (Regrets for my Old Dressing Gown) up to Le rêve de D'Alembert, where he plunges into the depths of the controversy as to the ultimate constitution of matter and the meaning of life. Diderot was not a coherent and systematic thinker, but rather "a philosopher in whom all the contradictions of the time struggle with one another" (Rosenkranz). He did not develop a comprehensive system of materialism, but he may have made some contributions to the atheistic materialist works of his friend Paul Henri Thiry, baron d'Holbach.

As a philosopher Diderot speculated on free will and held a completely materialistic view of the universe; he suggested all human behavior is determined by heredity. He therefore warned his fellow philosophers against an overemphasis on mathematics and against the blind optimism that sees in the growth of physical knowledge an automatic social and human progress. He rejected the Idea of Progress. In his opinion, the aim of progressing through technology was doomed to fail. He founded his philosophy on experiment and the study of probabilities. He wrote several articles and supplements concerning gambling, mortality rates, and inoculation against smallpox for the Encyclopédie. There he discreetly but firmly refuted d'Alembert's technical errors and personal positions on probability.

• Blum, Carol. Diderot: The Virtue of a Philosopher (1974)
• Crocker, Lester G. Diderot's Chaotic Order: Approach to a Synthesis (1974)
• Fellows, Otis E. Diderot, (1989)
• France, Peter. Diderot (1983)
• Furbank, P. N. Diderot: A Critical Biography. New York: A. A. Knopf, 1992. ISBN 0-679-41421-5.
• Gregory, Mary Efrosini. Diderot and the Metamorphosis of Species (Studies in Philosophy). New York: Routledge, 2006. ISBN 0415955513.
• Havens, George R. The Age of Ideas. New York: Holt, 1955. ISBN 0-89197-651-5.* Mason, John H. The Irresistible Diderot (1982)
• Simon, Julia. Mass Enlightenment. Albany: State University of New York Press, 1995. ISBN 0-7914-2638-6.
• Wilson, Arthur McCandless. Diderot (1972), the standard biography

Primary sources

• Diderot, Denis, ed. A Diderot Pictorial Encyclopedia of Trades and Industry, Vol. 1 (1993 reprint) excerpt and text search
• Diderot, Denis. Diderot: Political Writings ed. by John Hope Mason and Robert Wokler (1992) excerpt and text search, with introduction
• Main works of Diderot in English translation
• Hoyt, Nellie and Cassirer, Thomas. Encyclopedia, Selections: Diderot, D'Alembert, and a Society of Men of Letters. New

York: Bobbs-Merrill Company, 1965. LCCN 65-26535. ISBN0-672-60479-5.