Romero was born in New York City to a Cuban born father of Castilian Spanish parentage and a Lithuanian-American mother. The GENRE ONLINE.NET Interview - Writer and Director George A. Romero His father worked as a commercial artist. George A. Romero Biography (1940—) Romero attended Pittsburgh's Carnegie Mellon University. After graduating in 1960, George Romero he began his career shooting short films and commercials. One of his early commercial films, a segment for Mister Rogers' Neighborhood in which Mr. Rogers underwent a tonsillectomy, inspired Romero to go into the horror film business. He, along with nine friends, formed Image Ten Productions in the late 1960s, and produced Night of the Living Dead (1968). The movie, directed by Romero and co-written with John A. Russo, became a cult classic and a defining moment for modern horror cinema.

The films which followed were less popular: There's Always Vanilla (1971), Jack's Wife / Season of the Witch (1972) and The Crazies (1973) were not as well received as Night of the Living Dead or some of his later work. The Crazies, dealing with a biospill that induces an epidemic of homicidal madness, and the critically acclaimed arthouse success Martin (1977), a film that deals with the vampire myth, were the two well known films from this period. Like many of his films, they were shot in or around Pittsburgh.

In 1978, Romero returned to the zombie genre with Dawn of the Dead (1978). Shot on a budget of just $500,000, the film earned over $55 million worldwide and was named one of the top cult films by Entertainment Weekly in 2003. Romero made a third entry in his "Dead Series" with Day of the Dead (1985).

Between these two films Romero shot Knightriders (1981), another festival favorite about a group of modern-day jousters who reenact tournaments on motorcycles, and the successful Creepshow (1982), written by Stephen King, an anthology of tongue-in-cheek tales modeled after 1950s horror comics.

From the latter half of the 1980s and into the 1990s came Monkey Shines (1988), about a killer helper monkey, Two Evil Eyes (1990), an Edgar Allan Poe adaptation in collaboration with Dario Argento, the Stephen King adaptation The Dark Half (1993) and Bruiser (2000), about a man whose face becomes a blank mask.

Romero updated his original screenplay and executive produced the remake of Night of the Living Dead directed by Tom Savini for Columbia / Tristar in 1990. Romero had a cameo appearance in Jonathan Demme's Academy Award-winning The Silence of the Lambs in 1991 as one of Hannibal Lecter's jailers.

In 1998 he directed the live action commercial promoting the videogame Resident Evil 2 in Tokyo, Japan. The 30-second advertisement was live action and featured the game's two main characters, Leon S. Kennedy and Claire Redfield, fighting a horde of zombies while in Raccoon City's Police Station. The project was obvious territory for Romero; the Resident Evil series has been heavily influenced by Romero's "Dead" projects. The commercial was rather popular and was released in the weeks before the game's actual release, although a contract dispute prevented the commercial from being shown outside Japan. Capcom was so impressed with Romero's work, it was strongly indicated that Romero would direct the first Resident Evil film. He declined at first — "I don't wanna make another film with zombies in it, and I couldn't make a movie based on something that ain't mine" — although in later years he reconsidered and wrote a script for the first movie. It was eventually rejected in favor of Paul W. S. Anderson's version.

Universal Studios produced and released a remake of Dawn of the Dead in 2004, with which Romero was not involved. Later that year, Romero kicked off the DC Comics title Toe Tags with a six-issue miniseries titled The Death of Death. Based on an unused script that Romero had previously written as a sequel to his 'Dead Trilogy', the comic miniseries concerns Damien, an intelligent zombie who remembers his former life, struggling to find his identity as he battles armies of both the living and the dead. Typical of a Romero zombie tale, the miniseries includes ample supply of both gore and social commentary (dealing particularly here with corporate greed and terrorism - ideas he would also explore in his next film in the series, Land of the Dead). Romero has stated that the miniseries is set in the same kind of world as his 'Dead' films, but featured other locales besides Pittsburgh, where the majority of his films take place.

Romero, who lives in Toronto, Ontario, filmed a fourth "Dead" movie in that city titled Land of the Dead. The movie's working title was "Dead Reckoning". Its $16 million production budget was the highest of the four movies in the series. Actors Simon Baker, Dennis Hopper, Asia Argento, and John Leguizamo star in the film. It was released on June 24, 2005 to generally positive reviews.

Some critics have seen social commentary in much of Romero's work. They view Night of the Living Dead as a film made in reaction to the turbulent 1960s, Dawn of the Dead as a satire on consumerism, Day of the Dead as a study of the conflict between science and the military, and Land of the Dead as an examination of class conflict.

Romero collaborated with the game company Hip Interactive in creating a game called City of the Dead, but the game was canceled midway due to the financial problems of the company.

In June 2006, Romero began his next project, called Zombisodes. Broadcast on the web, they are a combination of a series of "Making of" shorts and story expansion detailing the work behind the film George A. Romero's Diary of the Dead. Shooting began in Toronto in July 2006.

In August 2006, The Hollywood Reporter made two announcements about Romero, the first being that he will write and direct a film based on a short story by Koji Suzuki, author of Ring and Dark Water, called Solitary Isle and the second announcement pertaining to his signing on to write and direct George A. Romero's Diary of the Dead, which follows a group of college students making a horror movie in the woods, who stumble on a real zombie uprising. When the onslaught begins, they seize the moment as any good film students would, capturing the undead in a cinema verite style that causes more than the usual production headaches. The film was independently financed, making it the first indie zombie film Romero has done in years.

After a limited theatrical release, Diary of the Dead was released on DVD by Dimension Extreme on May 20, 2008.

Shooting began in Toronto in September 2008 for Romero's newest zombie film. The title was Survival of the Dead and the production company was called Blank of the Dead. Originally, the film was reported to be a direct sequel to Diary of the Dead, but the film features a new cast of characters, and did not retain the first-person camerawork of Diary of the Dead. Filming commenced on the movie, with Alan Van Sprang starring who featured in Romero's Land of the Dead and Diary of the Dead, and the majority of the story taking place on an island. The film premiered at the 2009 Toronto International Film Festival. Prior to the May 28, 2010 theatrical release in the United States, Survival of the Dead was made available to Video On Demand and a special one night only sneak preview was aired May 26, 2010 on HDNet.the film was quite different then his others as it was a prequel to a Dead film that came before

Romero is currently writing two original Dead novels for Grand Central publishing, the first is The Living Dead: The Beginning, scheduled for release in July 2012, the second will follow sometime after.

Romero is currently separated from his wife, Christine Forrest, whom he met on the set of Season of the Witch; they have two children together. Romero became a Canadian Citizen in 2009.

Romero ranked his top ten films of all time for the 2002 Sight & Sound Greatest Films Poll (2002). They are The Brothers Karamazov, Casablanca, Dr. Strangelove, High Noon, King Solomon's Mines, North by Northwest, The Quiet Man, Repulsion, Touch of Evil and The Tales of Hoffman. Romero listed the films in alphabetical order, with special placement given to The Tales of Hoffman, which he cites as "my favourite film of all time; the movie that made me want to make movies."

On October 27, 2009, Romero was honored with the Mastermind Award at Spike TV's Scream 2009. The tribute was presented by longtime Romero fan Quentin Tarantino, who stated in his speech that the "A" in George A. Romero stood for "A fucking genius."