George Noory served nine years in the United States Naval Reserve as a full Lieutenant. He has said that he became fascinated with ufology and the paranormal as a child after having an out-of-body experience. As a teenager, Noory joined NICAP, the UFO organization that was a precursor to today's MUFON. Noory came to St. Louis in 1979 to be news director at KSDK channel 5 television before making the transition back to radio.

At the age of 28 he became the youngest news director in the country while at KSTP channel 5 in St. Paul, Minnesota.

While living in Detroit he worked in the news department of WCAR 1130 in Detroit, and later at Storer Broadcasting's Detroit CBS affiliate WJBK channel 2.

Noory was a broadcast major at the University of Detroit.

Noory's family is said to be of Lebanese Christian descent and his father was born in Cairo, Egypt, in 1922. According to Noory, he was brought up as a Roman Catholic and his mother was a devout Catholic. He says he believes in "a God," but some of his views, for instance, on reincarnation and the creation of the human race by aliens contradict mainstream Christian doctrine.

George Noory is currently divorced and has said on-air that he has been married twice. (He once referred to the odd-hours and stress of working as a late-night talk show host as one of the reasons for his failed marriages.) Noory has three children, and five grandchildren.

On May 15, 2009 Noory mentioned on the air, in passing, that he is a scuba diver.

Noory became a guest host for Coast to Coast AM (often abbreviated as "C2C") before replacing Ian Punnett as the Sunday night host. His first show was on April 28, 2001. On January 1, 2003, Noory took over week-night hosting duties from Art Bell, who had again decided to retire. On January 21, 2006, it was announced that Bell would return to C2C on Saturdays and Sundays, replacing Punnett on Saturdays, and Noory on the first two Sundays of the month. Bell returned to the air waves January 22, 2006 following his wife's death on January 5, 2006. While Punnett went on to host the Coast to Coast Live spin-off on Saturday nights, Noory remained the week-night host. With Noory as host and Art Bell doing the weekends, C2C remained one of the most listened to late night talk radio shows.

Noory has repeatedly announced on-air that he is committed to remaining the principal host of "Coast" until at least 2012, a year frequently called the so-called "Doomsday". His commitment is substantiated by a long-term contract with Premiere Radio Networks, a subsidiary of Clear Channel Communications which also produces radio programs for Rush Limbaugh, Randi Rhodes, Dr. Laura, and Glenn Beck. Noory has stood by his foreboding notion that 2012 will be a year of calamitous change on a global scale.

On the August 17, 2007 broadcast, George Noory made a statement during the third hour that he had a meeting a few weeks ago with [[Premiere Radio Networks]] outlining his tenure. He stated that he wishes to sign another five year contract in 2012, extending his hosting duties until about 2017. Noory went on to mention,  Noory has repeatedly vowed on-air that he will stay on C2C until he is "fragged out."

However, WorldNetDaily reports interest in a President Noory campaign in 2012. This might be response to comments such as:

On March 10, 2007, Noory introduced Art Bell for his Lifetime Achievement Award from "Radio & Records," the radio industry trade journal. The next week he replayed his introductory speech and Art Bell's acceptance speech. Noory revealed that although he has worked for C2C since 2001, that night was the first time he had met Art Bell in person.

Various mysterious phenomena-oriented message boards include discussions about Coast to Coast AM programming and its hosts. Some have described George Noory’s political persuasion as being paleoconservative along with the accusation that he panders to professional right-wing conspiracy theorists and immigration alarmists such as occasional C2C guests Jerome Corsi and Frosty Wooldridge.

In relation to C2C guests with religious themes, Mr. Noory has been accused on message boards of being biased in favor of Christianity on his program, because he has had more guests that identify themselves with Christianity than those associated with other faiths. Along those lines, Mr. Noory is known to allow Christian fundamentalists on his show who speak of the apocalypse.

On January 3, 2006, Noory's C2C guest was popular psychic Sylvia Browne, who implied on that broadcast that the trapped miners of the Sago Mine disaster would be found alive...this did not turn out to be the case. Because of Browne's inaccurate prediction, Noory has not invited her back to the show since and revealed this to listeners publicly on an October 3, 2007 C2C broadcast.

A positive characteristic of Noory that has been noted on message boards is that he is personable and polite with most of his call-in listeners, whom he addresses on a first name basis, as opposed to Art Bell's "old-school" approach in the way of being curt with many of his callers, and, in many instances, addressing them only as "Caller", instead of by his or her first name.

On September 19, 2006, Noory released his first book with co-author William J. Birnes, titled Worker in the Light: Unlock Your Five Senses And Liberate Your Limitless Potential. New York: Forge. ISBN 0-7653-1087-2.