I had to live ten years in New York. It was then a simple town, with few street lights north of Forty-second street. Now the place is pretty terrible to me, perhaps the ugliest city in the world. I decided that the only way to get out of New York was to write a successful novel. So I tried with The Spenders and when I got a substantial advance from publishers, I quit my job and beat it for the high hills of Colorado.

...Harry Leon Wilson

• Zigzag Tales from the East to the West (1894)
• The Spenders: A Tale of the Third Generation (1902) illustrated by Rose Cecil O'Neill; adapted into the 1923 film The Spenders.
• The Lions of the Lord, a Tale of the Old West (1903) illustrated by Rose Cecil O'Neill
• The Seeker (1904) illustrated by Rose Cecil O'Neill
• The Boss of Little Arcady (1905) illustrated by Rose Cecil O'Neill
• Ewing's Lady (1907)
• The Man from Home (1908) co-written with Booth Tarkington; adapted into two films, The Man from Home (1914) and The Man from Home (1922).
• Cameo Kirby (1908) co-written with Booth Tarkington; adapted into the 1936 film Cameo Kirby.
• Foreign Exchange (1909) co-written with Booth Tarkington
• Springtime (1909) co-written with Booth Tarkington; adapted into the 1914 film Springtime.
• If I Had Money (1909) co-written with Booth Tarkington
• Your Humble Servant (1910) co-written with Booth Tarkington
• Bunker Bean (1913) illustrated by Frederic R. Gruger; adapted into three films, His Majesty, Bunker Bean (1918), His Majesty, Bunker Bean (1925) Bunker Bean (1936).
• Ruggles of Red Gap (1915) illustrated by Frederic R. Gruger; adapted into three films, Ruggles of Red Gap (1923), Ruggles of Red Gap (1935) and Fancy Pants (1950).
• The Man from Home: A Novel (1915) based on the play
• Somewhere in Red Gap (1916) illustrated by John R. Neill
• Life (1919) play
• The Gibson Upright (1919) co-written with Booth Tarkington
• Ma Pettengill (1919)
• The Wrong Twin (1921) illustrated by Frederic R. Gruger
• Merton of the Movies (1922) adapted into three films, Merton of the Movies, Make Me a Star (1932) and Merton of the Movies (1947)
• So This Is Golf! 1923)
• Oh, Doctor! (1923) adapted into the two films, Oh, Doctor! (1925) and Oh, Doctor! (1937).
• Ma Pettengill Talks (1923)
• Professor How Could You! (1924)
• Tweedles (1924) co-written with Booth Tarkington
• Cousin Jane (1925)
• Lone Tree (1929)
• How's Your Health? (1930) co-written with Booth Tarkington
• Two Black Sheep (1931)
• When in the Course-- (1940)