She started her business, Janis Spindel Serious Matchmaking, Inc. in 1993. According to her website, she created this business after she had matched fourteen different couples together and they all ended up getting married within one year. Her company is headquartered in New York City on the Upper East Side of Manhattan and in the summer months, she opens up her office out in the Hamptons in addition to her headquarters in New York.. Although she is located in New York, she travels all over the country and even Canada for her clients. Her website was launched in 2005. She originally worked with both men and women as her clients, but has now narrowed down her clientele to only men and she specializes in upscale professionals who range in ages of 27 to 78.
Spindel is a former fashion executive. Prior to matchmaking, she was the proprietor of 9 retail locations of "Mommy and Me."
She is involved in multiple charities and charitable events including The Libby Ross Foundation, Susan G. Komen Foundation, City Meals On Wheels and St. Judes Hospital.
Her first book, Get Serious About Getting Married: 365 Proven Ways to Find Love in Less Than a Year was published by Harper Collins/Regan Books in January 2006. The book hit the New York Times Best Seller list upon its release.
Her second book, “How to Date Men: Dating Secrets from Americas Top Matchmaker” was released in August 2007. It was published by Plume/U.S. Penguin Group, and also hit the New York Times Best Seller list. An article in New York Times addressed the issues that the book touches upon. “Ms. Spindel’s guide addresses typical benchmarks like the first and second date, a relationship’s failure to thrive and adjustment issues”