Wayne was born and raised in Shreveport, Louisiana. She began reading when she was four years old, and quickly began making weekly trips to the library to find books to read. In 1984, she married and moved to New Orleans, where she enrolled in a writing course and joined a professional writing organization.
Her books have appeared on the Waldenbooks Bestselling List for romance. She has been nominated four times for a Romantic Times Reviewer's Choice Award, winning twice with Surprise Package and Attempted Matrimony. Romantic Times has also nominated her for a Career Achievement Award.
Wayne currently lives just north of Houston, Texas.