Andrews' early work includes short stories published in anthology books. Andrews was part of the Writer's Bloc club that originated on Wizard Magazine's Wizard World website.

He has worked on Incredible Hulk, Ultimate X-Men, Gen¹³, Amazing Spider-Man and The Matrix Comics.

Andrews wrote and drew a four-issue mini-series for Marvel known as Reign set 35 years in the future starring a retired Spider-Man.

Design

He has also done work on album design, such as the Beta Band's third studio album Heroes to Zeros and Tegan and Sara's 2002 album, If It Was You, as well as directing their music video "Living Room". Andrews has also directed multiple award winning short films and PSA.

Films

In October 2010 Andrews released his debut feature film Altitude starring Jessica Lowndes (90210) and Julianna Guill, a supernatural thriller about five friends on a small aircraft lost in a supernatural storm.

His follow up feature film, an action movie named The Hunted, will be produced by Gale Anne Hurd (Terminator, Aliens, Armageddon) for Valhalla Pictures.

Interior comics work includes:

• The Writers’ Bloc Anthology (1997), Writers' bloc annual '98 (1998) & Writers' bloc annual '99 (1999)
• Wonderlanders #1-2 (artist only, Oktomica Comics, 1999)
• Intrigue #1-2 (pencils only, with writer/inker Howard M. Shum, Image Comics, 2000)
• Ben Grimm and Logan (artist, 3-issue mini-series, Marvel Comics, 2000)
• Gen¹³ #64-65 (artist only, with writer & cover artist Adam Warren, Wildstorm, circa 2001)
• Spider-Man's Tangled Web #10 (writer & artist, Marvel, 2001)
• Marvel Mangaverse: Spider-Man (writer & artist, one-shot, Marvel, 2002)
• Spider-Man: Legend of the Spider Clan (writer only, mini-series, Marvel, 2002)
• X-Men Unlimited #37 (writer, cover artist & penciller of some interior pages, Marvel, 2002)
• Ultimate X-Men #23-24 (artist, with writer Mark Millar, Marvel, 2002)
• Thundercats/Battle Of The Planets (one-shot) (writer and artist, DC/Wildstorm, 2003)
• Year One mini-series (artist, with writer Zeb Wells, Marvel, 2004)
• Wolverine #32 (artist, with writer Mark Millar, Marvel, 2005)
• Reign (artist and writer, 4-issue mini-series, Marvel, 2006)
• Astonishing X-Men: Ghost Boxes #2- (artist, with writer Warren Ellis, Marvel, January 2009-ongoing)

Covers

• Spider-Man #27-29 (Marvel, 2001)
• Amazing Spider-Man Volume 2, #37-39 (#478-480) (Marvel, 2001—2002)
• Incredible Hulk #38-54 (Marvel, 2002—2003)
• Ultimate Adventures #1-6 (Marvel, 2002—2003)
• Black Panther #6-7 (Marvel, 2005)
• Amazing Spider-man #522 (Marvel, 2005)
• Wolverine #34-35 & 37-40 (Marvel, 2005—2006)
• G.I. Joe vs Transformers #1 (Image, 2003)
• Iron Fist (Marvel, 2008)
• Dead of Night (Marvel, 2008)

He has been recognized for his comics work by winning the "Outstanding Comicbook Artist" Award (2005) at Canada's first national award for comics, the Joe Shuster Awards for "Spider-Man/Doctor Octopus: Year One". He has been nominated for an Eisner Award and won the Squiddy Award for "Best Comics Cover Artist" (2002).