In 1956, Brown left Antioch College in Ohio for one year to attend the Central School of Arts and Crafts in London. There, she began to study etching. After graduating from Antioch, Brown returned to the Central School for another year to fine-tune her technique.

In the summer of 1959, while on a holiday trip to Edinburgh, Brown noticed an old etching press in the backyard of her rooming house. The landlady offered the press to Brown, saying it had been there since World War II. With the etching press in tow, Brown booked passage on a freighter going to San Francisco from Glasgow via the Panama Canal.

In 1962, Brown started Crown Point Press in a storefront space in Richmond, California. The following year she bought a house in Berkeley and ran the printmaking workshop out of her basement. In 1965, Brown began publishing the etching portfolios of Richard Diebenkorn and Wayne Thiebaud. The Press moved into a vacant hat factory on San Pablo Avenue in Oakland in 1971 and then to Folsom Street in San Francisco in 1986. Unfortunately, the Folsom Street space was lost in the Loma Prieta earthquake of 1989. In 1990, Crown Point moved to 20 Hawthorne Street in San Francisco where it resides today.

In recent years, Brown has shifted much of her focus to writing and left the day to day operations of the press to director Valerie Wade who is a partner in the business. In 2006, Crown Point began publishing a series of books about printmaking, the Magical Secrets series. Brown wrote the first book in the series, Magical Secrets about Thinking Creatively: The Art of Etching and the Truth of Life, which highlights various creative processes artists have embraced while working in the Crown Point studio. Art on Paper magazine reviewed Magical Secrets about Thinking Creatively saying, “Brown combines printmaking, art history, memoir and how-to inspirational literature to address the creative process. She’s wise, forthcoming and down-to-earth”. In 2004, Brown wrote The North Pole, a book detailing her trip to the North Pole through photographs and interviews with travelers, scientists, and a polar archivist. Brown is also the author of a monthly video segment, The Three Minute Egg, where she discusses the creative process.

Over the years, Crown Point’s roster has grown to include over 100 artists from all around the world. Crown Point’s archives have been held at the Fine Arts Museums of San Francisco since 1991. A smaller archive is owned by the National Gallery of Art, Washington, D.C. Crown Point Press celebrated its twenty-fifth anniversary with an exhibition at the Museum of Modern Art in New York, and it’s thirty-fifth with a retrospective jointly organized by and shown at the National Gallery of Art, Washington, D.C. and the Fine Arts Museum of San Francisco at the California Palace of the Legion of Honor. Today, Crown Point Press publishes the work of five artists a year, hosts printmaking workshops and publishes a series of books about printmaking. The Press will be fifty years old in 2012.

Brown married Jeryl Parker in 1960 and had a son, Kevin Powis Parker, in 1961. Parker and Brown amicably separated in 1963 and later divorced. In 1983, she married conceptual artist Tom Marioni. They make their home in San Francisco.