Crime Reporter Samantha Adams is working on a book called American Weird when her boyfriend persuades her to join him at a barbecue cookoff in Tupelo, Mississippi. As Harry puts it, the King's birthplace "ought to be lousy with weird". Besides, they're driving there in a genuine pink cadillac. Also driving toward Tupelo is Mary Ann McClananah, who more or less killed her third husband, Carlin. She's discovered Carlin was already married to a woman in Tupelo who'll collect the life insurance, unless Mary Ann does something about it.
Then an 18-wheeler driven by a novice Elvis impersonator blows Mary Ann off the road into a snake farm. Before you can say "Hound Dog", Sam's giving mouth to mouth to a barbecue contestant zapped by his own electric smoker, then things really start to cook up!