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Laboratory Correlates of Immunity to Influenza - A Reassessment: Informal Scientific Workshop, Bergen, May 2002 (Developments in Biologicals)
Laboratory Correlates of Immunity to Influenza A Reassessment Informal Scientific Workshop Bergen May 2002 - Developments in Biologicals Author:F. Brown, L. R. Haaheim, J. M. Wood, Geoffrey C. Schild For some 30 years, it has been a rule of thumb that antibody to influenza haemagglutinin, induced by natural infection or vaccination, is a universal and useful marker of immunity to influenza. It now seems important to re-examine this hypothesis. Knowledge of the mechanisms of acquired influenza immunity and correlations with measurable laborat... more »ory parameters is clearly of importance in understanding influenza epidemiology and vaccine-induced immunity. While immunity is certainly multi-factorial, involving both B and T cell responses, any comprehensive assessment is complicated by the capacity of the virus to undergo extensive and frequent antigenic variation. The aim of this workshop was to review the methods available for assessing immune responses and their advantages and disadvantages; and, to present information on immune responses to the various vaccine types and attempt to draw possible conclusions on their value in assessing protective immunity.« less