He has written for television programs The Office on NBC, for which he (with Stupnitsky) is credited.

He has written for an independent short film entitled Flush and he has one upcoming project slated: an untitled CollegeHumor movie. There are reports surfacing regarding about Eisenberg along with Stupnitsky writing a screenplay for a new installment of Ghostbusters.

Along with Stupnitsky, he plays one of the Vance Refrigeration delivery guys (Gino) present in several episodes of The Office.

He graduated from Connecticut College in 1999, and was once a contestant on the game show "Pyramid."

His first acting role was in a One Act play called "Emergency," where he played the 2nd Specialist.

He and Gene wrote the screenplay for the movie Year One. Eisenberg wrote with Stupnitsky currently the storybook of Ghostbusters III.

He has directed two episodes of "The Office" with Gene Stupinsky titled "Michael Scott Paper Company" and "The Lover". He is not credited for directing "Michael Scott Paper Company" although in a commentary of the episode, Gene Stupinsky mentions that they could not put both of their names in directing the episode. He and Stupinsky directed the webisode series, "The Outburst," a spinoff of the office which is available to watch on NBC.com.