Throughout her career, Eberstadt has written for a variety of magazines and newspapers, including National Review Online, Policy Review, The Weekly Standard, Commentary, the Wall Street Journal, Los Angeles Times, London Times, and the American Spectator. Her work has also appeared in First Things magazine, where she is a contributing writer.

She is also the author of numerous influential essays, including "Why Ritalin Rules," "Home-Alone America," "Eminem is Right," "How the West Really Lost God," and "Is Food the New Sex?" (Policy Review), and "The Vindication of Humanae Vitae," "How Pedophilia Lost its Cool," and "Christianity Lite (First Things)."

From 1990 to 1998, Eberstadt was executive editor of National Interest magazine. Between 1985 and 1987, she was a member of the Policy Planning Staff at the U.S. State Department and a speechwriter for then Secretary of State George P. Shultz. In 1984-85 she was a special assistant to Ambassador Jeane J. Kirkpatrick. Eberstadt is also a former managing editor of the Public Interest.