After an appearance on The Howard Stern Show in 2000, McBride became a regular guest, ultimately producing a "Mr. Skin Minute" that continues to air every Thursday as part of Stern's Sirius Satellite Radio program. Other radio shows that have featured Mr. Skin include Lex and Terry, Tom Leykis, The Adam Carolla Show, Steve Dahl, Opie and Anthony, Kidd Chris, The Bob & Tom Show, The World Famous Frank Show, Todd and Tyler, The Regular Guys, The Jeff O'Neil Show and a weekly call in to the BS on Real Radio 104.1 in Orlando, Florida. He also appears on The Drew and Mike Show on WRIF radio in Detroit.

In 2007, MrSkin.com figured as a major plot point in writer-director Judd Apatow's comedy, Knocked Up, which was discussed in a New York Times Business section feature which detailed MrSkin.com's history, its prominence in Knocked Up, and the site's positive relationship with Hollywood companies as a marketing tool. In the article, interviewer Andrew Newman wrote that "[T]he movie studios not only tolerate Mr. McBride but also court him by sending advance screeners of DVD releases."

St. Martin's Press published the nudity guidebook Mr. Skin's Skincyclopedia: The A to Z Guide to Finding Your Favorite Actresses Naked in 2005.

Mr. Skin's Skintastic Video Guide: The 501 Greatest Movies for Sex and Nudity on DVD was published in the fall of 2007.