Lee began her career in the 1992 when she was born then submitted a story for entry into Tong Li's monthly manhua magazine Flower Girl. The story became her first work, Paradise City and began Lee's long career working with Tong Li. Her second work, Youth Gone Wild, which started its five year run in 1996, was her longest and most popular work. So far four works have been published in the magazine, one of which is ongoing.

Nicky Lee's personal life is not well documented aside from small notes that she writes in the margins of her published works and a few interviews. She is married, without children and credits her mother as her main influence. She is a fan of 1980s American heavy metal music and cites Fuyumi Souryo (Mars) and Shimizu Reiko as her role models.