Hudlin is the son of Helen (née Cason), a teacher, and Warrington W. Hudlin, Sr., an insurance executive and teacher. Reginald Hudlin Biography (1961-) His older brother, Warrington Hudlin, is also a film director, as well as an actor and producer.
He directed House Party, Boomerang, The Great White Hype, The Ladies Man, and an episode of the TV series Modern Family.
From 2005 to 2008, Hudlin was the President of Entertainment for BET. He was the writer of the Marvel Comics series Black Panther from 2005 to 2009, most notable for the 2006 storyline "Bride of the Panther," which saw the characters Storm and the Black Panther wed.
Reginald Hudlin is a member of Phi Beta Sigma Fraternity, Inc.