Bube received his B.S. in physics from Brown University in 1946, and his M.A. (1948) and Ph.D. (1950) in physics from Princeton University.
He was a researcher at RCA Laboratories in Princeton, New Jersey from 1948 to 1962. Thereafter he taught at Stanford University where he was an associate professor from 1962 to 1964, when he became professor of materials science and electrical engineering. He served as his department's chair from 1975 to 1986, and is now an emeritus professor
For over twenty years he also conducted an undergraduate seminar at Stanford University on "Issues in Science and Christianity" Its cancellation in 1988 by Stanford University and its re-instatement the following year has been cited as a case of censorship in academia.
Bube is a member of:
The American Physical Society (fellow)
The American Association for the Advancement of Science (fellow)
The American Society for Engineering Education
The American Scientific Affiliation (fellow, member of executive council from 1964 to 1968, vice-president in 1967, president in 1968, editor of its journal from 1969 to 1983, emeritus fellow from 2009)
Defense of theistic evolution
In the 1970s, whilst he was editor of the Journal of the American Scientific Affiliation Bube defended the viewpoint of theistic evolution in that journal. One such article on this topic would receive in-journal peer-review by Baptist theologian Bernard L. Ramm, Canadian historian and Reformed scholar W. Stanford Reid, Fuller theologian Paul King Jewett, and Christian apologist Alvin Plantinga.
Bube was born in Providence, Rhode Island to Edward Ella Neser and Ella (Baltteim) Bube. He married Betty Jane Meeker in October 9, 1948 and they had four children: Mark Timothy, Kenneth Paul, Sharon Elizabeth, Meryl Lee. His son Mark T. Bube is the General Secretary for Foreign Missions of the Orthodox Presbyterian Church.