While in the early stages of his comic book career, Remender worked in animation on such films as The Iron Giant, Anastasia, Titan A.E. and The Adventures of Rocky and Bullwinkle. He penciled also the final mock comic book cover in the opening sequence of Ultraviolet and taught animation and comic art part time at the Academy of Art University in San Francisco.

He has illustrated album covers and promo art for punk/metal bands such as NOFX, 3 Inches of Blood, Pitch Black, Lagwagon and No Use for a Name.

Remender illustrated the comic book adaptation of the movie Man With the Screaming Brain, which was published in 2005 by Dark Horse Comics and year later he drew the series The Last Christmas, which was written by Brian Posehn with Gerry Dugan and inked by Hilary Barta.

On January 8, 2007 it was announced on his column Against The Grain that he would be teaming up with French artist Paul Renaud for a Red Sonja one-shot published by Dynamite Entertainment titled "Vacant Shell". He is also working on the horror line Crawl Space with Kieron Dwyer, which will include stories like XXXombies. He had previously worked with Dwyer on Sea of Red and Night Mary.

Remender was working on the Dark Horse Comics series The End League, as well as launching a giant robot series Gigantic, he will also be relaunching Fear Agent and starting a new series at Image Comics called Sorrow.

He became co-author of Punisher War Journal with Matt Fraction from issue #19 to 25 and then was the main writer on the new and eighth Punisher series. IDW Publishing also released a "master edition" of Black Heart Billy. In April 2009, Remender signed an exclusive writing contract with Marvel Comics but was still able to release the series The Last Days of American Crime through Radical Comics.

He served as a writer on Electronic Art's game Dead Space and is currently the lead writer for the upcoming video game Bulletstorm, currently in development by People Can Fly (in association with Epic Games) to be published by Electronic Arts.

Comics work includes:

• Captain Dingleberry (Slave Labor Graphics, 1999)
• Black Heart Billy (IDW, 2000-2009)
• Doll and Creature (Image, 2005)
• Night Mary (IDW Publishing, 2005)
• Sea of Red (with Salgood Sam & Kieron Dwyer, Image Comics, 2005)
• Strange Girl (with Eric Nguyen, Image Comics, 2005)
• Fear Agent #1-27 (with Tony Moore, Image Comics and Dark Horse Comics, October 2005- present)
• Doll and Creature (Image Comics, 2006)
• Red Sonja: "Vacant Shell" (with Paul Renaud, one-shot, Dynamite Entertainment, 2007)
• XXXombies (with Tony Moore and Kieron Dwyer, Image Comics, 2007)
• Sorrow (with co-author Seth Peck and art by Francesco Francavilla, 4-issue mini-series, Image Comics, August 2007 - March 2008)
• The End League #1-9 (with Mat Broome, Dark Horse Comics, January 2008 - November 2009)
• Punisher War Journal #19-25 (with co-author Matt Fraction, Marvel Comics, July 2008 - January 2009)
• Gigantic (with Eric Nguyen, Dark Horse Comics, 5-issue limited series, November 2008 - January 2010)
• Punisher vol. 8 #1- (with Jerome Opeña and Tan Eng Huat, ongoing series, Marvel Comics, March 2009 - ongoing)
• Thunderbolts #137 (with Mahmud A. Asrar, Marvel Comics, December 2009)
• Avenger of the Supernatural #1-5 (with Jefte Palo, Marvel Comics, December 2009 - April 2010)
• The Last Days of American Crime (with Greg Tocchini, 3-issue mini-series Radical Comics, December 2009 - ongoing)

Interviews

• Interview with Remender on the Comic Geek Speak podcast