Much of his fiction centers on gay themes and several of his novels are named after archetypes of gay male culture. Rodi himself is openly gay. The Chicago settings of his books also reflect his background.
Rodi's short fiction is collected in a number of anthologies, including Men on Men 5 and Neil Gaiman's Book of Dreams. His comic book work has appeared in Marvel Comics, the DC Comics imprint Vertigo, and other independent publishers. He was also well known in comic book circles during the '60s and '70s as a prolific writer of "letters to the editor" (as Bob Rodi).
Rodi was a founding member of the Chicago-area performance group The Pansy Kings and contributed plays and performed at the Live Bait Theatre.
His novel Kept Boy is under option to Warner Bros. and Rodi is adapting it for the screen.