Shifra Horn was born in Tel Aviv. She lives in the Gilo neighbourhood of Jerusalem. After majoring in Bible Studies and Archeology at the Hebrew University of Jerusalem, she earned an MA in Bible Studies. Horn also studied mass communications and completed a teaching degree.
Horn worked as an educational officer for the World Union of Jewish Students, and helped to organize the airlift of Ethiopian Jews to Israel. Horn also participated in the campaign to free Soviet and Syrian Jews, producing films and written material.
In the course of her work with Jewish students from oppressed communities around the world, she discovered a village of Jewish Marranos who had kept their Jewish identity secret for over 500 years. Horn's activity in the village of Belmonte in northwest Portugal resulted in the entire population converting fully to Judaism.
Horn was a spokesperson for the Israel Absorption Ministry until her departure for Japan, where she served as Far East correspondent for the Israel Defense Forces Radio station and Ma'ariv daily newspaper for five years. Horn worked as the director of the Tokyo Jewish Community Center and taught Bible Studies and Hebrew at the Bible College in Ginza, Tokyo.
Upon her return to Jerusalem, she opened a public relations firm, and lectured on Japan and literary topics. Her books have been translated from Hebrew into English, French, Dutch, German, Italian, Greek, Mandarin and Turkish.
Horn won the WIZO Prize (1997) and the Publishers` Association's Gold and Platinum Book Prizes for all four of her bestselling novels. She was nominated Literary Woman of the Year by the financial daily Globes (2002), and received the Prime Minister's Prize (2005) and the Brenner Prize (2006).