Salomon Naumovich Rabinovich (Salomon Nochem Vevik) was born in 1859 into a Hasidic family in the shtetl of Voronko, Kiev Governorate, Imperial Russia. His father, Menachem-Nukhem Rabinovich, was a rich merchant at that time. However, a failed business affair plunged the family into poverty and Sholem Aleichem subsequently grew up in reduced circumstances. When he was 13-years old, the family moved to Pereiaslav, where his mother, Chaye-Esther, died in a cholera epidemic. His first venture into writing was an alphabetic glossary of the epithets used by his stepmother. At the age of fifteen, inspired by Robinson Crusoe, he composed a Jewish version of the novel. He adopted the pseudonym Sholem Aleichem (lit. "peace be with you" or "hello"). In 1876, after graduating from school in Pereyaslav, he spent three years tutoring a wealthy landowner's daughter, Olga (Golde) Loev. On May 12, 1883, they married, against the wishes of her father. They had six children. Their son, Norman Raeben, became a painter and their daughter Lyalya (Lili) Kaufman, became a Yiddish writer. Lyalya's daughter Bel Kaufman, also a writer, was the author of Up the Down Staircase, which was made into a successful film.

At first, Sholem Aleichem wrote in Russian and Hebrew. From 1883 on, he produced over forty volumes in Yiddish, thereby becoming a central figure in Yiddish literature by 1890. Most writing for Russian Jews at the time was in Hebrew, the liturgical language used largely by learned Jews. Yiddish, however, was the vernacular language of nearly all literate East European Jews. It was often derogatorily called "jargon", but Sholem Aleichem used this term in an entirely non-pejorative sense.

Besides his prodigious output of Yiddish literature, Sholem Aleichem also used his personal fortune to encourage other Yiddish writers. In 1888-1889, he put out two issues of an almanac, Di Yidishe Folksbibliotek ("The Yiddish Popular Library") which gave important exposure to many young Yiddish writers. In 1890, Sholem Aleichem lost his entire fortune in a stock speculation, and could not afford to print the almanac's third issue, which had been edited but was subsequently never printed. Over the next few years, while continuing to write in Yiddish, he also wrote in Russian for an Odessa newspaper and for Voskhod, the leading Russian Jewish publication of the time, as well as in Hebrew for Ha-melitz, and for an anthology edited by Y.H. Ravnitzky. It was during this period that Sholem Aleichem first contracted tuberculosis.

After 1891, Sholem Aleichem lived in Odessa, and later Kiev. In August 1904, Sholem Aleichem edited Hilf: a Zaml-Bukh fir Literatur un Kunst ("Help: An Anthology for Literature and Art"; Warsaw, 1904) and himself translated three stories submitted by Tolstoy (Esarhaddon, King of Assyria; Work, Death and Sickness; Three Questions) as well as contributions by other prominent Russian writers, including Chekhov, in aid of the victims of the Kishinev pogrom. In 1905, he left Russia with some reluctance, forced by waves of pogroms that swept through southern Russia. He resettled in New York City but failed to establish himself in the Yiddish theatre there. His family, meanwhile, set up house in Geneva, Switzerland. Sholem Aleichem soon discovered that his income was far too limited to sustain two households, and he left for Geneva. Despite his great popularity, many of his works had not generated much revenue, and he was forced to take up an exhausting schedule of lecturing in order to make money to support his family.

In July, 1908, while on a reading tour in Russia, Sholem Aleichem collapsed on a train going through Baranowicze. He was diagnosed with a relapse of acute hemorrhagic tuberculosis and spent two months convalescing in the town's hospital. He later described the incident as "meeting his majesty, the Angel of Death, face to face", and claimed it as the catalyst for writing his autobiography, Funem yarid [From the Fair]. During Sholem Aleichem's recovery, he missed the First Conference for the Yiddish Language, held in 1908 in Czernovitz; his colleague and fellow Yiddish activist Nathan Birnbaum went in his place. Sholem Aleichem spent the next four years living as a semi-invalid; only eventually becoming healthy enough to return to a regular writing schedule. During this period the family was largely supported by donations from friends and admirers.

In 1914, most of Sholem Aleichem's family emigrated to the United States, where they made their home in the Lower East Side, Manhattan. Sholem Aleichem's son Misha was ill with tuberculosis at the time and therefore inadmissible under United States immigration laws. Misha remained in Switzerland with his sister Emma, and died in 1915, an event which put Sholem Aleichem into a profound depression.

Sholem Aleichem died in New York in 1916, aged 57, while still working on his last novel, Motl, Peysi the Cantor's Son, and was laid to rest at Mount Carmel cemetery in Queens. At the time, his funeral was one of the largest in New York City history, with an estimated 100,000 mourners. The next day, his will was printed in the New York Times and was read into the Congressional Record of the United States.

Sholom Aleichem's narratives were notable for the naturalness of his characters' speech and the accuracy of his descriptions of shtetl life. Early critics focused on the cheerfulness of the characters, interpreted as a way of coping with adversity. Later critics saw a tragic side in his writing.

Sholem Aleichem's will contained detailed instructions to his family and friends; both in regards to immediate burial arrangements as well as to how Sholem Aleichem wished to be commemorated and remembered on his annual yartzheit. He told his friends and family to gather, "read my will, and also select one of my stories, one of the very merry ones, and recite it in whatever language is most intelligible to you." "Let my name be recalled with laughter," he added, "or not at all." The celebrations continue to the present-day, and, in recent years, have been held at at the Brotherhood Synagogue on Gramercy Park South in New York City, where they are open to the public.

In 1997, a monument dedicated to Sholem Aleichem was erected in Kiev; another was erected in 2001 in Moscow.

The main street of Birobidzhan is named after Sholem Aleichem; streets were named after him also in other cities in the USSR, among them Kyiv, Lviv, Zhytomyr and Mykolaiv. In 1996, a stretch of East 33rd Street in New York City between Park and Madison Avenue was renamed "Sholem Aleichem Place". Many streets in Israel are named after him.

Postage stamps of Sholem Aleichem were issued by Israel (Scott #154, 1959); USSR (Scott #2164, 1959); Romania (Scott #1268, 1959); and Ukraine (Scott #758, 2009).

An impact crater on the planet Mercury also bears his name. MESSENGER: MErcury Surface, Space ENvironment, GEochemistry, and Ranging

On March 2, 2009 (150 years after his birth) the National Bank of Ukraine issued an anniversary coin celebrating Aleichem with his face depicted on it.

In Melbourne, Australia a small yiddish school is named after him.

Sholem Aleichem was an impassioned advocate of Yiddish as a national Jewish language, one which should be accorded the same status and respect as other modern European languages. He did not stop with what came to be called "Yiddishism", but devoted himself to the cause of Zionism as well. Many of his writings present the Zionist case. In 1888, he became a member of Hovevei Zion. In 1907, he served as an American delegate to the Eighth Zionist Congress held in The Hague.

Sholem Aleichem was often referred to as the "Jewish Mark Twain" because of the two authors' similar writing styles and use of pen names. Both authors wrote for both adults and children, and lectured extensively in Europe and the United States. When the two finally met late in life, however, Twain retorted that he was considered the "American Sholem Aleichem."

Sholem Aleichem had a mortal fear of the number 13. His manuscripts never have a page 13; he numbered the thirteenth pages of his manuscripts as 12a and his headstone carries the date of his death as "May 12a, 1916".

English-language collections

• The Best of Sholom Aleichem, edited by R. Wisse, I. Howe (originally published 1979), Walker and Co., 1991, ISBN 0-8027-2645-3.
• Tevye the Dairyman and the Railroad Stories, translated by H. Halkin (originally published 1987), Schocken Books, 1996, ISBN 0-8052-1069-5.
• Nineteen to the Dozen: Monologues and Bits and Bobs of Other Things, translated by Ted Gorelick, Syracuse Univ Press, 1998, ISBN 0-8156-0477-7.
• A Treasury of Sholom Aleichem Children’s Stories, translated by Aliza Shevrin, Jason Aronson, 1996, ISBN 1-56821-926-1.
• Inside Kasrilovka, Three Stories, translated by I. Goldstick, Schocken Books, 1948 (variously reprinted)
• The Old Country, translated by Julius & Frances Butwin, J B H of Peconic, 1999, ISBN 1-929068-21-2.
• Stories and Satires, translated by Curt Leviant, Sholom Aleichem Family Publications, 1999, ISBN 1-929068-20-4.
• Selected Works of Sholem-Aleykhem, edited by Marvin Zuckerman & Marion Herbst (Volume II of "The Three Great Classic Writers of Modern Yiddish Literature"), Joseph Simon Pangloss Press, 1994, ISBN 0-934710-24-4.

Autobiography

• Funem yarid, written 1914-1916, translated as The Great Fair by Tamara Kahana, Noonday Press, 1955; translated by Curt Leviant as From the Fair, Viking, 1986, ISBN 0-14-008830-X.

Novels

• Stempenyu, originally published in his Folksbibliotek, adapted 1905 for the play Jewish Daughters.
• Yossele Solovey (1889, published in his Folksbibliotek)
• Tevye's Daughters, translated by F. Butwin (originally published 1949), Crown, 1959, ISBN 0-517-50710-2.
• Mottel the Cantor's son. Originally written in Yiddish. English version: Henry Schuman, Inc. New York 1953
• In The Storm
• Wandering Star
• Marienbad, translated by Aliza Shevrin (1982, G.P. Putnam Sons, New York) from original Yiddish manuscript copyrighted by Olga Rabinowitz in 1917
• The Bloody Hoax

Young adult literature

• Menahem-Mendl, translated as The Adventures of Menahem-Mendl, translated by Tamara Kahana, Sholom Aleichem Family Publications, 1969, ISBN 1-929068-02-6.
• Motl peysi dem khazns, translated as The Adventures of Mottel, the Cantor's Son (young adult literature), translated by Tamara Kahana, Sholom Aleichem Family Publications, 1999, ISBN 1-929068-00-X. Also appeared as Mottel the Cantor's son (Henry Schuman, Inc. New York 1953)
• The Bewitched Tailor, Sholom Aleichem Family Publications, 1999, ISBN 1-929068-19-0.

Plays

• The Doctor (1887), one-act comedy
• Der get (The Divorce, 1888), one-act comedy
• Di asifa (The Assembly, 1889), one-act comedy
• Yaknez (1894), a satire on brokers and speculators
• Tsezeyt un tseshpreyt (Scattered Far and Wide, 1903), comedy
• Agentn (Agents, 1905), one-act comedy
• Yidishe tekhter (Jewish Daughters, 1905) drama, adaptation of his early novel Stempenyu
• Di goldgreber (The Golddiggers, 1907), comedy
• Shver tsu zayn a yid (Hard to be a Jew, 1914)
• Dos groyse gevins (The Big Lottery / The Jackpot, 1916)
• Tevye der milkhiker, (Tevye the Milkman, 1917, performed posthumously)

Miscellany

• Jewish Children, translated by Hannah Berman, William Morrow & Co, 1987, ISBN 0-688-84120-1.