Daius Whitney is a brilliant computer pioneer turned destructive hacker. His first goal is to bring down the company that he founded but saw swallowed up by a large conglomerate. His plan is to foul up the reservations network used by every major airline on Wednesday Novenber 21, the day before Thanksgiving, and the busiest travel day of the year. Exactly according to plan the virus he inserts through his company's software reduces nearly every airport in the country to chaos, and brings mobs of holiday travelers to the edge of riot.
Soon, the embittered computer pioneer's talents are enlisted by a notorius Columbian drug baron, who wants him to disrupt a far more sensitive computer network. When the ex-Navy fighter pilot and computer security expert Scott Vandenberg is called upon to stop the sinister plot, Virus takes off at breakneck speed and doesn't let up until the final page.