Bob Layton learned to read comics from the age of four, explaining that his "older sister Sue became bored with reading the same comic to me about fifty times. (It was a Showcase featuring The Challengers of the Unknown.)"

After leaving high school, Layton began "playing comics dealer . . . selling them out of his apartment in Indianapolis," through which (in 1973) he met Roger Stern, while the latter was working for a radio station in Indianapolis.

CPL

Ultimately, Layton and Stern began publishing a fanzine called CPL (Contemporary Pictorial Literature) out of Layton's apartment.

Stern recalls that, "CPL started out as Bob's sale catalog. Bob was drawing the covers and including little reviews written by some of his customers. By issue #5, it turned into a small 'zine with a catalog insert, and I started writing short articles for it. I eventually became an editor of sorts."

CPL rapidly became a popular fan publication, and led to the two forming an alliance with Charlton Comics to produce and publish "the now-famous Charlton Bullseye magazine." During the mid-1970s, both Marvel and DC were publishing in-house "fan" publications (F.O.O.M. and The Amazing World of DC Comics respectively), and Charlton wished to make inroads into the superhero market, as well as "establish a fan presence", leading to the alliance with CPL to produce the Charlton Bullseye. This led to Charlton giving Layton and Stern "access to unpublished material from their vaults by the likes of Steve Ditko, Jeff Jones and a host of others." This association with Charlton (and Bill Pearson, production manager) in turn led to Layton becoming acquainted with the legendary Wally Wood, with whom he apprenticed. This apprenticeship led to work for Charlton (on anthology titles, but not working from the Charlton offices), Marvel and DC, while still publishing fanzines.

Marvel Comics and DC Comics

Part of Layton's role as Wally Wood's apprentice included him occasionally delivering artwork to "NYC from Connecticut." Layton recalls that:

One day, I was in the Marvel offices . . . handing in Woody's pages to the production dept. So, I used the opportunity to show my samples around while I had 'my foot in the door'. When I passed the art director's office, I heard John Romita on the phone, frantically trying to find someone to ink a desperately late issue of Iron Man [by George Tuska]. Like an idiot, I stuck my head in his doorway and said I could get the job done in the four or five days that was left on the schedule. It was an utter fabrication . . . but I really wanted to work for Marvel Comics! Johnny gave me the pages and said, 'Show me what you can do, kiddo.'

Layton's reaction was one of panic, and his search for help to meet the deadline led him to Dick Giordano and Neal Adams' Continuity Associates where his "fledgling contemporaries," the Crusty Bunkers ("Terry Austin, Bob Wiacek, Joe Rubinstein, Bob McLeod, Joe Brosowski, Carl Potts and a host of others") were able to lend a hand and help him finish the book.

A month later, Layton received a package containing "an entire issue of pencils on the Champions", and discovered that he was "the new regular inker on the book." He worked for Marvel "for about a year, then signed an exclusive one-year contract with DC ... after they made me 'an offer I couldn't refuse'."

Layton began work for DC Comics in Spring/Summer 1977, taking up regular inking duties on All Star Comics, as well as inking multiple issues of Secret Society of Super-Villains, DC Super Stars and DC Special, among others. In Nov/Dec 1977, he inked the first issue of David Michelinie's Star Hunters, and after a number of other shorter inking jobs, moved back to Marvel in late 1978, to ultimately take up one of his best remembered roles.

In 1978, Layton reunited with Star Hunters writer David Michelinie, to co-write a re-imagined Iron Man. The two would become regular writing and creative partners, and began their collaboration on Iron Man with November, 1978's issue #116, taking over the writing from Bill Mantlo. The two would create some of the best loved Iron Man/Tony Stark stories and transform the title from a low-end book into one of Marvel’s all-time best sellers, staying with the title until #154 (Michelinie wrote a couple more issues without Layton), and then returning for a second lengthy run from February 1987's issue #215 to #250 (Dec 1989).

Layton continued to ink and work on covers for titles such as The Incredible Hulk, Captain America, Power Man and Iron Fist, and, later, Micronauts (among others), but Iron Man was his primary concern. In September 1982, however, he launched one of the earliest miniseries ever, writing, penciling and inking the four-issue Hercules: Prince of Power. Its success spawned a four-issue sequel in 1984, also written, drawn and inked fully by him, and a 1988 graphic novel (#37 in the "Marvel Graphic Novel" series) - Full Circle. Around this time, he also designed the highly successful Marvel Secret Wars toy line for Mattel, which deal formed the impetus behind the 1984 Secret Wars event.

Layton continued to work on various issues of a number of titles, before, in February 1986, reviving the original X-Men characters in the series X-Factor, which he wrote and co-inked (first issue only), with artwork by Jackson Guice. Layton wrote the first five issues, before handing over the series to Louise Simonson, who would make it her own. After Michelinie and Layton finished their second Iron Man run with issue #250, Layton returned to the title briefly to write, pencil and ink #254, and then to write #256 (as a stop-gap before Byrne and John Romita Jr. took over with #258) in May 1990 before leaving Marvel. A year later, he returned to the comics industry to ink Jim Shooter's Magnus, Robot Fighter #1, from Valiant Comics.

Valiant Comics

Bob Layton was one of the chief architects of the Valiant Universe, along with Jim Shooter, Barry Windsor-Smith, Steven J. Massarsky, and Jon Hartz. He co-created a number of the core characters including X-O Manowar, and later became Editor-in-Chief and Senior Vice President, during which time he controlled the company during its most profitable period.

His first Valiant work appeared in Magnus, Robot Fighter #1 (May, 1991), in which he inked Art Nichols' artwork from Jim Shooter's script. He would continue with Magnus for five issues (and produce covers to issue #9), while also inking the inaugural issues of Solar, Man of the Atom, which he also edited. In February, 1992, he co-created (with Shooter and Steve Englehart) and penciled the first issue of X-O Manowar, (after which he handed over the core art duties to Sal Velluto, but provided inks for #2). The following month he drew the cover to David Michelinie's Rai

In August, 1992, he co-wrote, edited and inked Archer & Armstrong #1, edited and provided pencilwork on Eternal Warrior #1, and inked Barry Windsor-Smith on Unity #0. Starting in November, 1992, he co-edited with Dark Horse publisher Mike Richardson the Predator/Magnus, Robot Fighter two-issue crossover, and in December was again inking (and editing) a Michelinie-written comic: H.A.R.D. Corps. Layton also edited Turok, Dinosaur Hunter, Deathmate and Secret Weapons before (in November, 1993) writing the first of thirteen issues of The Second Life of Doctor Mirage. He was also editing a vast array of titles during this time, for which he won the Editor of the Year award (1993), as voted by the readers of the then-new comics magazine, Wizard.

His workload decreased greatly towards the end of 1994, in large part due to the sale of Valiant (Voyager Communications, Inc.) to video game giant Acclaim Entertainment for $65,000,000.00 USD, a deal in which Layton played an instrumental part. His story concepts and design work on Turok, Dinosaur Hunter was also utilized to great effect by Acclaim when the video game became the largest selling title in Acclaim’s history, with over 1.5 million units sold. He continued to work editorially, however, largely for the new Acclaim imprint Armada Comics, for which he edited a number of The Gathering comics during 1995-6. He also edited Bob Hall's four-issue Armed & Dangerous (Apr-Jul 1996), and returned to X-O Manowar for which he wrote the final three issues.

After a several-year association with Valiant/Acclaim, Layton moved to Florida for a short retirement. (Although he found time to write the first eleven (of twelve) issues of Acclaim's Doctor Tomorrow between 1997 and 1998, also inking a couple of issues, notably #6 which was drawn by Dick Giordano, who also resided in Florida and was something of a mentor to Layton.)

Return to DC and Marvel

In 1998, he returned to DC, re-teaming briefly with penciler Sal Velluto on a story in September 1998's The New Gods Secret Files and Origins, before collabotaring with his fellow Floridian and artistic friend/mentor Dick Giordano on several projects. The two-issue prestige format Elseworlds tale Batman: Dark Knight of the Round Table was co-drawn and co-inked by the both of them, from a script by Layton and debuted a month after their six-issue mini-series The L.A.W. , which ran from September 1999 to February 2000, with script and inks by Layton, and full pencils by Giordano. The two also wrote a second Batman Elseworlds tale, Batman: Hollywood Knight a three-issue mini-series which told the story of a Serials-actor who became convinced he was The Batman. It was written by Layton with pencils and inks by Giordano.

Between Elseworlds, Layton worked with Marvel Comics on an Iron Man reunion, which saw him produce the four-part limited series Iron Man: Bad Blood with his long-term Iron Man collaborator David Michelinie. The comic ran from September to December, 2000, with art by Layton and, as previously, the plot was a joint effort, and the final script by Michelinie. Layton then stayed at Marvel for a short time, teaming up with Dan Jurgens as inker on Captain America (#38-50), as well as inking a short run on The Avengers (#44-47). He also inked the Dan Jurgens-drawn The Power Company: Manhunter and part of Just Imagine Stan Lee... Secret Files and Origins for DC in March 2002.

2000s

In December 2000, Layton launched Future Comics, with Dick Giordano, Allen Berrebbi, and David Michelinie. Layton acted as editor-in-chief, Berrebbi was CFO and director of marketing, Michelinie was head writer, Giordano was art director, and Skip Farrell was the publisher. Between 2000 and 2002, they prepared to revolutionize the direct market system by bypassing distributors and selling direct to customers and shops through the Internet.

In August, 2002, Freemind #0 was released. Edited and inked by Layton, written by Layton and Michelinie, and with pencils by Giordano, it was followed by another title, Metallix, before the company bowed to pressure and signed with distributor Diamond in an attempt to maximize sales while maintaining their independent approach. Ultimately, after three titles (the third was Deathmask), and seventeen total issues, the company was not making enough money to survive, and it folded, with one announced title ... Peacekeeper ... unpublished.

Layton's work continues to be collected in multiple trade paperback collections. In 2006, he produced a number of variant covers to issues of Superverse Comics' Zoom Suit, written by John Taddeo, and in 2007 his work was featured in issues of Marvel's encyclopedic All-New Official Handbook of the Marvel Universe A to Z: Update. Layton is currently working for Marvel as a freelance artist and writer on several projects including Iron Man: Legacy of Doom mini-series, Iron Man: The End, as well potential Hercules projects.

He continues to enjoy "doing commission work," writing:

How often do you, as an artist, get an opportunity to revisit a drawing and correct your mistakes? It’s also a lot less work that doing a monthly, 22-page comic. And occasionally, the fans come up with some great concepts fore [sic] me to execute.

He says that he "miss[es] telling stories," and to that end has showcased unpublished issues of Future Comics properties on his website, where he also presents his "new, serialized comic" Colony, with art by Giordano, and which "is a project that [Layton has] been developing for [over] 10 years and is currently making the rounds in Hollywood." Other potential film deals for the Future Comics characters are also reportedly semi-ongoing.