Falsani graduated from Wheaton College in 1992, and holds master's degrees in journalism from the Medill School of Journalism at Northwestern University, and in theological studies from Garrett-Evangelical Theological Seminary in Evanston, Illinois.

Falsani is the author of the critically acclaimed book, Inside the Spiritual Lives of Public People, a collection of 32 spiritual profiles of famous "culture shapers" including Bono of U2, Nobel Peace Prize winner Elie Wiesel, author Anne Rice, and professional basketball player Hakeem Olajuwon. Inside the Spiritual Lives of Public People, Falsani's first book, was published by Farrar, Straus & Giroux on March 14 2006, to critical acclaim, launching Sarah Crichton Books, the newest imprint at the New York publishing house. The paperback edition of The God Factor was published in June 2007. Falsani's debut was named among the best non-fiction books of 2006 by the Christian Science Monitor.

In early 2007, Falsani left the Chicago Sun-Times as its religion reporter after 10 years on the news beat in Chicago, but continued on as the paper's religion columnist until Jan. 13, 2010. In 2007 she signed with the publishing giant Zondervan for two new non-fiction books, A Field Guide For Grace ... a spiritual memoir and travelogue published September 1, 2008 ... and The Gospel According to the Coen Brothers, published in October 2009.

Falsani is a columnist for the nationally syndicated Religion News Service as well as a columnist and contributing editor at Sojourners magazine.

Since 2004, she has been the author of a religion-and-popular culture blog called "The Dude Abides".

Interview with Obama on religion

In March of 2004, Falsani conducted an interview with eventual President of the United States Barack Obama. At the time of the interview, Obama was a state senator from Illinois and the nominee of the Democratic Party of Illinois for the U.S. Senate in the 2004 election. The interview focused on Obama's religious beliefs and spiritual predilections, and is widely regarded by journalists and political observers as the most in-depth and detailed interview Obama has granted to date regarding his views on religion and faith.

Falsani was born and raised in Connecticut. Since 1997, Falsani has been married to Maurice Possley, a Pulitzer Prize-winning, former Chicago Tribune investigative reporter and author. The couple live have a son and live in Laguna Beach, California.