Felice Picano was born in New York City in 1944. He was graduated cum laude from Queens College in 1964 with English department honors. He founded SeaHorse Press in 1977, and The Gay Presses of New York in 1981 with Terry Helbing and Larry Mitchell; he was Editor-in-Chief there. He was an editor and writer for The Advocate, Blueboy, Mandate, Gaysweek, and Christopher Street. He was the Books Editor of The New York Native. At The Los Angeles Examiner, San Francisco Examiner, New York Native, Harvard Lesbian & Gay Review and the Lamdba Book Report, he was a culture reviewer. He has also written for OUT and OUT Traveller. With Andrew Holleran, Robert Ferro, Michael Grumley, Edmund White, Christopher Cox, and George Whitmore, he founded The Violet Quill considered to be the pathbreaking gay male literary nucleus of the 20th Century.
In his memoir Men Who Loved Me, he describes his close friendship with the poet W. H. Auden. In his later memoir/history, Art & Sex in Greenwich Village, he writes about contacts with Gore Vidal, James Purdy, Charles Henri Ford, Edward Gorey, Robert Mapplethorpe and many contemporary and younger authors.
Among those who Picano introduced to the public via his publishing companies were Dennis Cooper, Harvey Fierstein, Jane Chambers, Brad Gooch, Robert Gluck, Doric Wilson, and Gavin Dillard. Several of his novels have been national and international best-sellers, and they have been translated into fifteen languages.
A long time resident of Manhattan and Fire Island Pines, Picano has resided for periods of time in Los Angeles, San Francisco, London, England, and Berlin, Germany. He now lives in West Hollywood, CA.