Khoury recalls not being "completely enthralled by comic books until I discovered Star Wars #68 [(Feb, 1983)] from Marvel Comics." As a 12-year old Star Wars fan, Khoury was introduced to Marvel Comics, and
Khoury attended Saint Peter's College in New Jersey, where he wrote for the school paper and was a member of the Zeta Eta chapter of the Delta Sigma Pi fraternity. During his senior year (1995), he applied - and was accepted for - an autumn internship at Marvel Comics, with editor Ralph Macchio, and Macchio's assistant Matt Idelson. During the course of his (unpaid) five-month internship, Khoury recalled "[t]he only money I ever made at Marvel was $45 that Sir Michael Higgins gave me for assisting him on a lettering job," but that he was proud of the reader reaction to "stories that we'd pieced together mere weeks before." In January 1996, he helped "prep Captain America #451," including placing word balloons "with Mark Waid's approval."
Khoury graduated from St. Peter's College c. 1996.
In 2007, as author of Image Comics: Road to Independence, he moderated a reunion of all seven Image Comics founders - Erik Larsen, Jim Lee, Rob Liefeld, Todd McFarlane, Whilce Portacio, Marc Silvestri, and Jim Valentino - at the San Diego Comicon.
Khoury's main body of work has been produced for North Carolina-based publisher TwoMorrows Publishing. In 2001, he produced a companion to the Great British superhero Miracleman, detailing the genesis of that character from his Captain Marvel-origins to on-going legal wranglings over ownership. In particular, the volume featured extensive interviews with original series writer/creator Mick Anglo, Warrior magazine editor-publisher Dez Skinn and acclaimed author of the 1980s 'Marvel (Miracle) Man' revivial, Alan Moore. These were augmented with script excerpts, Moore's original proposal, artwork and interviews with other individuals who had worked on the series, including Chuck Austen, Rick Veitch, John Totleben, Neil Gaiman and Mark Buckingham.
The book was nominated for an Eisner Award in 2002.
From at least issue #21 (Aug, 2002) of TwoMorrows' Comic Book Artist magazine, Khoury contributed articles and columns, in particular focusing on 'lost' stories that were talked about, solicited or even worked on, but are unreleased. By issue #23, Khoury was described as the magazines "new assistant editor," rising later to a position of senior editor, while continuing to write for the award-winning publication.
Khoury has also worked for other TwoMorrows magazines, including The Jack Kirby Collector, Back Issue and Rough Stuff.
Khoury has also produced freelance work for publications including Creative Screenwriting, Newsarama, El Siglo, Comics Buyer's Guide, and contributed an interview to the book Spike Lee: Interviews (ed. Cynthia Fuchs). In January, 2008, Khoury began producing an irregular weekly column for Comic Book Resources entitled "Pop!," and featuring a mixture of reminiscences, 'lost stories,' interviews and analysis.
Khoury's other books include The Extraordinary Works of Alan Moore, an extensive reference guide to the Northampton-based English comics legend, and True Brit: A Celebration to the Great British Comic Book Artists. With co-writer Jason Hofius, Khoury has produced G-Force Animated: The Official Battle of the Planets book, and The Age of Heroes, and co-edited (with Eric Nolen-Weathington) two volumes in TwoMorrows' "Modern Masters" series spotlighting landmark comics illustrators - Vol. 6: Art Adams, and Vol. 10: Kevin Maguire.
A book on the various 'muck monsters' of comics (primarily Swamp Thing and Man-Thing) was solicited (to feature a cover by Frank Cho), but has yet to be released.