Search -
Calming the Brain: Benzodiazepines and Related Drugs from Laboratory to Clinic
Calming the Brain Benzodiazepines and Related Drugs from Laboratory to Clinic Author:Adam Doble, Ian Martin, David J. Nutt, Adam Doble Relief from anxiety without concomitant sedation has long been an unmet medical need. Calming the Brain: Benzodiazepines and Related Drugs from Laboratory to Clinic addresses the entire field of research in the area of minor tranquilizers and their application to current clinical practice in the treatment of anxiety and insomnia. The text descri... more »bes the molecular mechanism of action of benzodiazepines, focusing on the interaction of these drugs with the different isoform of the GABAA receptor and the consequences of this for brain function. The authors explore the clinical use of benzodiazepines and related drugs in the treatment of anxiety, insomnia, epilepsy, and as anesthetics, discussing the advantages and limitations of such treatments and the impact of the newer non-benzodiazepine drugs. They discuss the animal models available for evaluating the potential of these new therapeutic agents. Bringing together information on the neurochemical, molecular pharmacological, neurophysiological, behavioral and clinical properties of benzodiazepines, the book provides a coherent and comprehensive picture of current knowledge on these drugs, and thus paves the way for the design of new anxiolytic and hypnotic drugs.« less