Chopra was born in Boston, Massachusetts, the son of Deepak Chopra. Gotham was an undergraduate student at Columbia University.

He started his career as a correspondent and news anchor for Channel One News, a short television program shown in selected high schools throughout the United States, and went on to host the program 'Current Soul' for Current TV. In 2002, he published an account of his travels and interviews entitled Familiar Strangers: Uncommon Wisdom in Unlikely Places with Doubleday. He was story editor for the comic book Bulletproof Monk and executive producer for the 2003 film adaptation starring Chow Yun-fat. His first book, Child of the Dawn, a parable based on the principles of his father's highly successful book, The Seven Spiritual Laws of Success, was published in 1996, and written while Chopra was still an undergraduate college student at Columbia University.

Around the time he began his career at Channel One News, Chopra changed the spelling of his first name from the traditional "Gautama," which evokes the ancient spiritual teacher and founder of Buddhism, to "Gotham," a nickname for New York City and later appropriated as the fictional setting of the Batman comic book series. Chopra said that he changed his name because "Gotham" sounds more hip and that he was tired of "Gautama" being mispronounced in the United States. Rediff On The NeT: The Son Also Rises The pronunciation of both versions is very close.

Gotham is a partner in Chopra Media, with his sister, Mallika Chopra. Together they launched IntentBlog and Virgin Comics. In September 2008, Gotham and Virgin Comics co-founder, Sharad Devarajan led a management buyout of Virgin Comics and renamed the Company, Liquid Comics.

On July 3, 2009, Gotham gave an interview on CNN's Larry King Live at Neverland Ranch saying that he knew pop star Michael Jackson through his father for over two decades.

Following the Newark Airport Incident where Shahrukh Khan was detained for two hours, Gotham Chopra stated:

"It's not just American customs agents being provincial, it's the fact that I would guess that in India alone, there are several million Khans. I'm not joking. Khan is one of the most common Muslim names and India is not even an Islamic country. "Ghengis Khan," anyone? Khan is like Jones or Smith. This is how our security works in the US? This is how we are catching terrorists? Are you kidding me?"

Books

• Bulletproof Monk (story editor)
• Child of the Dawn
• Familiar Strangers: Uncommon Wisdom in Unlikely Places
• Walking Wisdom