Scudamore's first novel The Amnesia Clinic won the 2007 Somerset Maugham Award and was shortlisted for the Costa First Novel Award, the Commonwealth Writers' Prize, the Glen Dimplex Award and the Dylan Thomas Prize. It was described by Hilary Mantel as "A wonderful debut - witty, polished, fluent and effortlessly entertaining" and by the judges of the Costa Award as a "delightful book ... full of tall tales and fantasy".

His second novel, Heliopolis, was published in 2009. Writing in The Guardian, Henry Shukman commented that "In his second novel, set in contemporary São Paulo, Scudamore does not embed a transplant from his own culture in foreign soil. Instead he takes the plunge and boldly invests himself in a first-person narrator. The novel is cleverly pitched to explore the two socioeconomic poles of modern urban Brazil. And the writing is exemplary: you feel the hand of a natural at work, one whose command of tone is strong, and who has an instinctive feel for handling a story." The novel was longlisted for the 2009 Man Booker Prize.

He is married to Rose Grimond, the granddaughter of the Liberal politician Jo Grimond. In 2009 he was awarded a Visiting Fellowship at the University of East Anglia, and in 2010 he will take up a teaching post at the City University of Hong Kong. He lives in London.