"A child who is protected from all controversial ideas is as vulnerable as a child who is protected from every germ. The infection, when it comes- and it will come- may overwhelm the system, be it the immune system or the belief system.""I loved the house the way you would any new house, because it is populated by your future, the family of children who will fill it with noise or chaos and satisfying busy pleasures.""In my experience, there is only one motivation, and that is desire. No reasons or principle contain it or stand against it.""Your sons weren't made to like you. That's what grandchildren are for."
Born in Los Angeles, California, Smiley grew up in Webster Groves, Missouri, a suburb of St. Louis, and graduated from John Burroughs School. She obtained an A.B. at Vassar College, then earned an M.F.A. and Ph.D. from the University of Iowa. While working towards her doctorate, she also spent a year studying in Iceland as a Fulbright Scholar.
Smiley published her first novel, Barn Blind, in 1980, and won a 1985 O. Henry Award for her short story "Lily", which was published in The Atlantic Monthly. Her best-selling A Thousand Acres, a story based on William Shakespeare's King Lear, received the Pulitzer Prize for Fiction in 1992. It was adapted into a film of the same title in 1997. In 1995 she wrote her sole television script, produced for an episode of Life on the Street. Her novella The Age of Grief was made into the 2002 film The Secret Lives of Dentists. Her essay "Feminism Meets the Free Market" was included in the 2006 anthology Mommy Wars by Washington Post writer Leslie Morgan Steiner.
Thirteen Ways of Looking at the Novel (2005), is a non-fiction meditation on the history and the nature of the novel, somewhat in the tradition of E. M. Forster's seminal Aspects of the Novel, that roams from eleventh century Japan's Murasaki Shikibu's The Tale of Genji to 21st-century American women's literature.
From 1981 to 1996, Smiley taught undergraduate and graduate creative writing workshops at Iowa State University, continuing to teach there even after relocating to California.
In 2001, Smiley was elected a member of The American Academy of Arts and Letters. She participates in the annual Los Angeles Times Festival of Books in association with UCLA. Smiley chaired the judges' panel for the prestigious Man Booker International Prize in 2009.