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Leukotrienes As Mediators of Asthma and Inflammation: Basic and Applied Research (Advances in Prostaglandin, Thromboxane, and Leukotriene Research)
Leukotrienes As Mediators of Asthma and Inflammation Basic and Applied Research - Advances in Prostaglandin, Thromboxane, and Leukotriene Research Author:Sven-Erik Dahlen, Bengt Samuelsson, Per Hedqvist This volume presents the work of distinguished investigators who have conducted major studies in eicosanoid biology. The book provides an informative appraisal of the current state of the art in leukotriene and inflammation research, integrating both basic science and new clinical findings. The contributors address the growing body of evide... more »nce that leukotrienes represent a group of mediators that contribute significantly to the pathobiology of asthma and play a role in other diseases.The opening sections of the book deal with the mechanisms for synthesis of leukotrienes and new strategies for the inhibition of actions of leukotrienes. New experimental studies relevant to the biochemistry and physiology of leukotrienes in inflammation are also covered. Subsequent chapters report on the first studies with leukotrienes and anti-leukotriene drugs in human volunteers and asthmatics. In addition, the book examines the potential role of leukotrienes in rheumatoid arthritis, rhinitis, inflammatory bowel disease, and skin disorders. There is also a section discussing the biology of lipoxins and influences on inflammation and arachidonic acid metabolism by cytokines.« less