Shirshendu Mukhopadhyay was born in Bikrampur (currently in Munshiganj District), now in Bangladesh. He spent his childhood in Bihar and many places in Bengal and Assam accompanying his father, who worked in the railways. He passed intermediate from the Victoria College, Calcutta before taking a Masters in Bengali from the Calcutta University.
Mukhopadhyay started his career as a school teacher and is now on the staff of the Ananda Bazar Patrika at Kolkata. He is associated with the Bengali magazine Desh.
Spiritually, Mukhopadhyay is heavily influenced by the Hindu sub-sect of Anukul Thakur. Many of his books are dedicated with a salutation 'Ra-Swa'. Ra-Swa stands for Radha Swami (this is a standard salutation for followers of Anukul-Thakur).
A comics based on his book Bipinbabur Bipad was released. With artwork by Swapn Debnath, the 48-page comics was published in monthly issues of Anandamela (September 2006 to December 2006). Another story Nababganjer Agantuk, is now in the process of becoming an action comics by Visual Literature Entertainment, a group of new generation comics creators.
Shirshendu Mukhopadhyay has also penned thrillers like Shada Beral, Kalo Beral, and even started a series with detective Shabar Dasgupta in the lead. But the series was not successful, so he discontinued writing it.
His novel PatalGhor was adapted into a movie Patal Ghar by Abhijit Choudhury in 2003. Kaagajer bau was also adapted into a 2010 film by director Bappaditya Bandopadhyay.His novel 'Nabiganjer Daitto'was adapted into a movie Ajab Gayer Ajab Katha by Tapan Sinha.His novel 'Hirer Angti'was adapted into a movie Hirer Angti by Rituporno Ghosh.His novel 'Sadhubabar Lathi'was adapted into a movie Sadhubabar Lathi.
His first novel Ghunpoka was published in the annual Puja edition of Desh. His first children's novel was called Manojder Adbhut Baari.
Adult fiction
Ghunpoka
Parthibo
Maanab jamin
Paarapaar
Manojader adbhut baari: His first work,about a teenage boy named Manoj and his weird family. The story revolves around a photo of Prince, Manoj's family, teachers and neighbours.
Haripurer harek kaanda
Baangaler america darshan
Ekaadashi o bhut
Charadik
Golmal
Akranta
Pherighaat
Madhur janya
Shreshhha galpa
Galpa-samagra (2 volumes)
Ashukher pare
Aadam ibh o andhakaar
Ujaan
Kaagajer bau
Kaapurushh
Gati
Churi
Chokh
Jaal
Durbin
Young adult fiction
Nilu hajrar hatyaarahasya
Pidimer aalo
Phajal aali esechhe
Phulchor
Bikeler mrityu - Tells the story of Bobby Roy, an executive and Leena, his P.S.