Chivers was born on October 18, 1809, at Digby Manor, his father's plantation near Washington, Georgia. At age seven, he was introduced to poetry when he read William Cowper's "The Rose". In 1827, Chivers married his 16-year old cousin Frances Elizabeth Chivers. The two soon separated due to alleged meddling by Frances Chivers Albert, the wife of the poet's uncle, prior to the birth of their daughter in 1828. It has also been suggested their separation was due to abuse, though these rumors originated from the same uncle. After this incident, Chivers compared himself to Lord Byron, whose wife had also left him. Chivers went on to receive a degree in medicine in 1830 from Transylvania University in Kentucky. His thesis was titled "Intermittent and Remittent Fevers".

Chivers wandered throughout the West and North of the United States, publishing poetry in various places before returning to Georgia. In 1832, Chivers published The Path of Sorrow, a collection of poetry based on the events of his troubled first marriage. Two years later, he published Conrad and Eudora; or, The Death of Alonzo, the first fictionalized account of the actual 1825 murder case nicknamed the "Kentucky Tragedy". The work was later renamed Leoni, The Orphan of Venice. On November 21, 1834, Chivers married Harriet Hunt of Springfield, Massachusetts and the couple had four children, though all died young. Chivers and his first wife never legally divorced...one such suit was dismissed in court in 1835...but Georgia law invalidated marriage after a spouse's absence of five years or more. Though Chivers contributed to various newspapers and magazines, his poetry was turned down for publication by the Southern Literary Messenger in March 1835, which suggested he return to medicine and the "lancet and pill-box". Though the poems were not printed, unsigned commentary on them was presented in an editorial, referring to verses submitted by "T. H. C., M. D." The Lost Pleiad was self-published in New York in 1845 to initial success, though sales rapidly declined. In 1837, Chivers self-published Nacoochee; or, the Beautiful Star, With Other Poems. The volume was dedicated to his mother, who died a year later.

Relationship with Edgar Allan Poe

Chivers is best known for his association with Edgar Allan Poe and, in fact, it is through this relationship that Chivers and his work was rediscovered in the 20th century. The first interaction between the two was in 1840 though they did not meet until 1845 in New York. The two became friends and Chivers was willing to give Poe lifetime financial support if he moved to the South. Chivers appreciated Poe's ability and wrote that George Rex Graham was seriously underpaying Poe for his work on Graham's Magazine. "He ought to give you ten thousand dollars a year... It is richly worth it... [Graham] is greatly indebted to you. It is not my opinion that you have ever been, or ever will be, paid for your intellectual labours. You need never expect it, until you establish a Magazine of your own", he wrote, referring to Poe's plans to begin The Stylus. Even so, Chivers was concerned about Poe's reputation as a severe literary critic, cautioning him about "when you tomahawk people". Poe, in fact, had been hoping Chivers would lend his wealth as a financial backer for The Stylus and possibly even serve as a co-editor in its early planning stages. Chivers considered Poe's proposal but was not able to accept because of the death of his three-year-old daughter just over a week later.

Poe had written about Chivers in the second part of his "Autography" series, published in Graham's Magazine in December of 1841. Poe said:

The two had corresponded through letters but finally met in June or July 1845. Chivers visited Poe when Poe was sick and bedridden and when Poe's wife Virginia was in an especially difficult period of her struggle with tuberculosis. Chivers later recalled that Poe's voice was "like the soft tones of an Aeolian Harp when the music that has been sleeping in the strings is awakened by the Breezes of Eden laden with sweet Spices from the mountains of the Lord".

By September 1845, however, Chivers was lecturing Poe on the dangers of alcohol. A Prohibition, he said Poe was wasting his God-given talents by indulging in drink. "Why should a Man whom God, by nature, has endowed with such transcendent abilities, so degrade himself into the veriest automaton as to be moved only by the poisonous steam of Hell-fire?" he said. While Poe's wife Virginia was sick, Chivers had to carry Poe home after a night of excess.

Moreover, as attested to in an 1848 pamphlet titled Search After Truth, Chivers disagreed with Poe regarding aesthetics. This small booklet presents a series of dialogues between the Seer [Chivers] and Politian [Poe]. For Chivers, a poet should be a Shelleyan or Swedenborgian visionary intent on capturing mystic realms of experience in language. For Poe, the poet is merely a superior wordsmith. The wise Seer ultimately leads Politan to the truth.

After Poe's death

After Poe's death, Chivers accused Poe of plagiarizing both "The Raven" and "Ulalume" from his own work though other critics suggested Chivers's Eonchs of Ruby were a "mediocre restatement" of Poe's poems. The first poem of the collection, "The Vigil of Aiden", was an homage to Poe, using names like "Lenore" and the refrain "forever more!" On July 30, 1854, Chivers published an essay called "Origin of Poe's Raven" under the pseudonym Fiat Justitia, claiming that he inspired Poe to use trochaic octameter and the word "nevermore" in "The Raven". Chivers also suggested in the Georgia Citizen that Poe learned to write poetry from him. As literary scholar Randy Nelson wrote: "anybody who's read both Poe and Thomas Holley Chivers can see that one of them 'influenced' the other, but just who took what from whom isn't clear."

Even so, Chivers continued to praise and admire Poe (albeit careful to point out Poe's literary debt to him) and was one of the first to present a picture of the "real Poe" in the face of the sustained attacks on Poe's reputation by the Reverend Rufus Wilmot Griswold, the poet's literary executor. This correction took the form of a memoir now titled Chivers' Life of Poe, not published until 1952. Chivers said of Griswold that he "is not only incompetent to Edit any of [Poe's] works, but totally unconscious of the duties which he and every man who sets himself up as a Literary Executor, owe the dead." Chivers continued to defend Poe's reputation until the end of his life.

Final years and death

From 1845 to 1850, Chivers had been living with his wife in Georgia, then spent the next five years in the North. His poetry collection Eonchs of Ruby, A Gift of Love was published in 1851 with a subtitle meant to capitalize on the gift book trend. Chivers explained the title: "The Word Eonch is the same as Concha Marina...Shell of the Sea. Eonch is used... merely for its euphony." Throughout the collection, Chivers experiments with the sonic effects of words rather than their literal meaning. Atlanta: or the True Blessed Island of Poesy: A Paul Epic in Three Lustra was first published in three installments in the Georgia Citizen beginning in January 1853. Later that year, Memoralia; or, Philas of Amber Full of the Tears of Love was printed in Philadelphia, Pennsylvania and generally received unfavorably. Very shortly after, the same publisher brought out Virginalia; or, Songs of My Summer Nights, a collection made up of poems that were generally under 200 lines each, about half of which had previously been published in magazines.

By 1855, Chivers and his wife had moved back to Georgia and he predicted that the slavery issue would soon force his home state to break from the United States. A slaveholder himself, Chivers did not believe that slaves should be abused, though he still defended the institution against abolitionists. Struck with sudden illness, Chivers wrote his will before dying on December 18, 1858, in Decatur, Georgia. His last words were, "All is perfect peace with me." His last published work, a drama titled The Sons of Usna, had been published earlier that year. At the time of his death, Chivers had prepared several manuscripts of his literary theory with the intention of publishing them in several volumes of books and as part of a lecture series. In his will, he left one dollar for his first wife and their daughter.

In his poetry, Chivers made use of legends and themes from Native American culture, particularly the Cherokee, though often with Christian overtones. He was also heavily influenced by the work of François-René de Chateaubriand and Emanuel Swedenborg. Many of Chivers's poems included themes of death and sorrow, often using images of shrouds, coffins, angels, and reunions with lost loves in the afterlife. Religious conventions at the time made discussion of death popular, as was reflected in poetry. Because of his background as a doctor, Chivers was able to graphically depict the last moments before someone's death.

Chivers believed in a close connection between poetry and God and that true poetry could only be written through divine inspiration. He once wrote: "Poets are the apostles of divine thought, who are clothed with an authority from the Most High, to work miracles in the minds of men". He also wrote: "Poetry is the power given by God to man of manifesting... the wise relations that subsist between him and God", and it "is that crystal river of the soul which runs through all the avenues of life, and after purifying the affections of the heart, empties itself into the Sea of God". In Nacoochee, the preface states: "Poetry is that crystal river of the soul which runs thorugh all the avenues of life, and after purifying the affections of the heart, empties itself into the Sea of God." In his introduction to Atlanta, written in 1842 but not published until 1853, Chivers gives a lengthy discussion of his poetic theory, pre-dating many ideas Poe would suggest in "The Poetic Principle" (1850). Chivers, for example, suggests that poems should be short to be successful: "No poem of any considerable length... can be pleasing to any well-educated person for any length of time". He also experimented with blank verse as early as 1832 and his 1853 collection, Virginalia, included mostly poems using blank verse.

At least for a time, he considered Elizabeth Barrett Browning the best contemporary English poet. Like many from his time, Chivers called for the development of a distinctive American literature and he especially encouraged young writers. Poe called the 1845 poetry collection The Lost Pleiad "the honest and fervent utterance of an exquisitely sensitive heart." Overall, he called Chivers "one of the best and one of the worst poets in America". William Gilmore Simms offered conditional praise of Chivers's poetry as well: "He possesses a poetic ardor sufficiently fervid, and a singularly marked command of language. But he should have been caught young, and well-bitted, and subjected to the severest training... As an artist, Dr. Chivers is yet in his accidence." Simms also commented that his works were too gloomy and melancholy.

Though Chivers built up a mild reputation during his lifetime, counting Algernon Charles Swinburne among his admirers, his fame faded away quickly after his death. Other writers that acknowledged his influence included Dante Gabriel Rossetti, William Michael Rossetti, and Rudyard Kipling. Others, however, were more critical. One anonymous reviewer, possibly Evert Augustus Duyckinck, joked that Chivers was formulaic and suggested the formula included 30% Percy Bysshe Shelley, 20% Poe, 20% "mild idiocy", 10% "gibbering idiocy", 10% "raving mania" and 10% "sweetness and originality". Literary scholar S. Foster Damon wrote that Chivers would have had a stronger reputation if he were born in the North and "the literary coteries there would surely have pruned and preserved him... But the time and space were against him."