Welborn had three children in her first marriage before divorcing. She was married to Michael Dubruiel, with whom she has two children, until his death in 2009.

Welborn was one of the first and most popular authors of a Catholic-themed blog. She has changed her blog's name and server on three occasions. The four successive blogs have been In Between Naps (amywelborn.blogspot.com), Open Book (amywelborn.typepad.com), Charlotte Was Both (amywelborn.wordpress.com), and Via Media (blog.beliefnet.com/ViaMedia). Open Book received almost 12,000 page views per day when it was still active. In the summer of 2007, Welborn terminated Open Book to focus on fiction. After being unable to stay away from blogging, Welborn started Charlotte Was Both.

Welborn considers blogging to be an alternative venue to expose unpopular views.

Welborn holds a BA in Honors History from the University of Tennessee and an MA in Church History from Vanderbilt Divinity School.