Search - Amiloride-Sensitive Sodium Channels, Physiology and Functional Diversity (Current Topics in Membranes, Volume 47) (Current Topics in Membranes)

AmilorideSensitive Sodium Channels Physiology and Functional Diversity - Current Topics in Membranes, Volume 47 - Current Topics in Membranes
Author: Dale J. Benos

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. Th...  more »e sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.

Key Features

* Summarizes current state of amiloride-sensitive sodium channel field

* Analyzes structure-function of epithelial sodium channels

* Discusses immunolocalization of epithelial sodium channels

* Examines hormonal regulation of sodium channels

* Discusses sodium channels in lymphocytes, kidney, and lung

* Considers mechanosensitivity of sodium channels

* Provides ideas on sodium channels and disease  « less

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ISBN-13: 9780121533472
ISBN-10: 0121533476
Publication Date: 4/1999
Pages: 416
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Publisher: Academic Press
Book Type: Hardcover
Members Wishing: 0
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