Archives of neurology and psychiatry Author:American Medical Association Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: A CASE OF ACROMEGALIA ASSOCIATED WITH BRAIN TUMOR WILLIAM A. BRYAN, M.D., And SHI CHI UYEMATSU, M.D. HATHORNE, MASS. INTRODUCTION The principal interes... more »t in this case is the relation between the cerebral tumor and the acromegalic symptoms. To prove which of these was primary or causative is impossible, but we will endeavor to show that the entire picture can be explained on the assumption that the tumor was the original lesion and the polyglandular symptoms were dependent on pressure with resultant biochemical changes. There is abundant support in the literature for this contention. This patient has been under observation at various hospitals since March, 1914, with the diagnosis of acromegalia, the tumor mass not being suspected. CLINICAL OBSERVATIONS History.—J. B., Case 18457; Necropsy 2072. The patient was admitted to the Danvers State Hospital, Pel). 15. 1915. The family history was negative for nervous and mental diseases. The patient was born in 1865. Birth and early development were uneventful. He was married in 1890 and had six children. His wife had had no miscarriages. At the time his illness began, he was a foreman in a shop. He had no venereal disease. He used alcohol and tobacco moderately. His trouble began about 1895. The first symptoms were a sense of pressure and discomfort in the head with enlargement of the head, hands and feet, bowing of both legs and loss in weight. Progress was gradual, and the patient continued to work as a machinist. In the spring of 1903 he sustained a so-called shock. This caused paralysis of the left arm and leg and incapacitated him for about three months. In 1910 he began to have severe, almost constant headaches. At times they were diffuse but usually they were occipital. The pain in the hands became more acute. He ...« less