A film version of Niffenegger's debut novel, The Time Traveler's Wife (2003), starring Eric Bana and Rachel McAdams, was released in August 2009.She has also written a graphic novel, or "novel in pictures" as Niffenegger calls it, called The Three Incestuous Sisters. This book tells the story of three unusual sisters who live in a seaside house. The book has been compared to the work of Edward Gorey.
Another graphic novel, The Adventuress, was released in September 1, 2006. The 2004 short story 'The Night Bookmobile' is currently being serialised in 'Visual Novel' format in The Guardian.
In March 2009, Niffenegger sold her second novel, Her Fearful Symmetry, for an advance of $5 million to Charles Scribner's Sons, a unit of Simon & Schuster, after a fiercely contested auction. The book was released on 1 October 2009 and is set in London's Highgate Cemetery where, during research for the book, Niffenegger acted as a tour guide.
She is currently working on a third novel called The Chinchilla Girl in Exile, about a girl called Lizzie Varo, who suffers from hypertrichosis (excessive bodily hair).
Art and academia
She is also a professor in the Interdisciplinary Book Arts MFA Program at the Columbia College Chicago Center for Book and Paper Arts. She is the founding member of T3 or Text 3, an artist and writer's group that also performs and exhibits in Chicago.
Niffenegger is also a Faculty member at the North Shore Art League where she teaches the Intermediate & Advanced Printmaking Seminar.
Niffenegger is an alumna of the Ragdale Foundation, where she is also a board member. She described herself as "somewhere in the spectrum of agnosticism and atheism" and ascribed her disbelief to her Catholic background.