Debra Webb grew up on a farm outside Scottsboro, Alabama. Although her family was not wealthy, Webb cites her parents' hard work as teaching her "that I could be anything, do anything if I wanted it badly enough and was willing to work hard enough." Webb had always created stories in her head, and when she turned nine she began to write them down.
After she married, Webb continued to invent stories but grew too busy to write them down. To help pay the family's bills, she sold vacuum cleaners and took jobs working in factories or at fast food restaurants. After the birth of their first child, Webb's husband joined the military, and she entered college. After Webb earned a degree in Business Administration, her husband was stationed in Berlin, Germany. Webb worked as a secretary in the commanding general's office. She and her family returned to the United States in 1985, and Webb accepted a position as an executive secretary at NASA.
In 1995, after a bout with a chronic illness, Webb decided to focus on her stories again. For three years, she researched the romance novel market and wrote. In 1998, she sold her first novel, a comedic romance novel, to Kensington Books' Precious Gems line. Six weeks later, she sold a second novel, this time to Harlequin's Intrigue line.
Her first Harlequin Intrigue concerned a private investigator agency run by Victoria Colby. Since that book, Webb has written over two dozen additional novels that are connected to the Colby Agency. In 2007, she began a second series, The Equalizers, which focuses on Victoria Colby's son, Jim Colby.
Webb is a Romantic Times Career Achievement Winner. She has been nominated five times for Romantic Times Reviewer's Choice Awards, winning twice.