Both Elizabeth Towne and her second husband William E. Towne were for many years associated with the International New Thought Alliance (INTA), and served on its board in various capacities. She served as the president of INTA in 1924.

Towne was the founder and publisher of Nautilus Magazine, a journal of the New Thought Movement that ran from 1898 through 1953, when she brought it to a close due to her advancing age (she was 88 years old at the time). She also operated the Elizabeth Towne Company, which published an extensive list of New Thought, metaphysical, self-help, and self-improvement books by herself and writers such as William Walker Atkinson, Kate Atkinson Boehme, Paul Ellsworth, Orison Swett Marden, Edwin Markham, Clara Chamberlain McLean, Helen Rhodes-Wallace, William Towne, and Wallace Wattles.

The title page of Towne's book The Life Power and How to Use it is shown in the opening sequence of the 2006 movie The Secret, and the film presents many of the ideas that she promoted, along with those of Wallace Wattles and William Walker Atkinson.

In addition to the many articles and editorials she wrote for Nautilus Magazine during its 55-year history, books by Elizabeth Towne include:

• Experiences in Self-Healing
• Fifteen Lessons in New Thought or Lessons in Living
• Happiness And Marriage
• Health Through New Thought and Fasting (with Wallace Wattles)
• How to Grow Success
• How to Use New Thought in Home Life
• Lessons in Living
• The Life Power and How to Use It
• Joy Philosophy
• Just How to Concentrate
• Just How to Cook Meals Without Meat
• Just How to Train Children and Parents
• Just How to Wake the Solar Plexus Elizabeth Towne Co. 1906.; repr. 1926.
• Practical Methods for Self-Development: Spiritual, Mental, Physical
• You and Your Forces
• Your Character (reprinted as How to Read Character)