Several of Little's books, such as Mine for Keeps and From Anna, focus on children who have a disability or are affected by a person with a disability. As many of her books were written several decades ago, they now serve as examples of how children with disabilites were previously raised and treated by society. Another frequent theme is adoption and foster care, as shown in Home from Far and Willow and Twig. Children often find homes and families throughout the course of the novel, whether it consists of rediscovering the importance of their family, being reunited with family or creating a new family in their new situation. While the novels often touch on very sad events, ranging from serious illness, abuse and death, the endings are usually positive and show the resilence of mankind.