Her first novel, Kissing Kate, was selected an ALA Best Books for Young Adults for the year 2004. It was named by Booklist as one of the "Top Ten Youth Romances" of the year, as well as one of the "Top Ten Books by New Writers". Her middle-grade novel, Eleven, came out 2004, along with Twelve, which came out in 2007. Myracle published The Fashion Disaster that Changed My Life in 2005. Thirteen was released in March 2008.

She also wrote Rhymes with Witches, which is included in Anita Silvey's "500 Great Books for Teens", and was nominated for "Best Books for Young Adults" by the American Library Association. Bliss, which came out in 2008, is its prequel. She also has a book entitled How to Be Bad with E. Lockhart (The Boyfriend List, The Boy Book) and Sarah Mlynowski (Bras and Broomsticks).

The "IM" books (ttyl (talk to you later), ttfn (ta ta for now), l8r, g8r (later gator)) are about 3 friends, Zoe, Maddie, and Angela who experience typical high school drama: boys, drugs, alcohol, parties, driving, murderous rampages, and college prep. The novels ttyl and ttfn were both New York Times Best Sellers, and ttyl was the first-ever novel to be written entirely in instant messages. Most of Myracle's novels take place in Atlanta, Georgia and are inspired by her childhood friends and experiences, and her large diverse family.The series in order goes ttyl, ttfn, l8r g8r, and lastly bff.

According to the American Library Association, Myracle was the most banned author of 2009. Her books continue to be challenged in school libraries, usually for scenes of alleged sexuality, homosexuality, or alcohol use. Scholastic Books nearly refused to carry "Luv Ya Bunches" at its national school book fair events due to the fact that the book features lesbian mothers. Scholastic recanted its initial decision after a large internet outcry.

Series

Winnie Years Series

1. Eleven (2004)
2. Twelve (2007)
3. Thirteen (2008)
4. Thirteen Plus One(2010)

Internet Girls series

1. ttyl (2005)
2. ttfn (2007)
3. l8r, g8r (2008)
4. bff (2009) (A special fill-in-the-blank book.)

Other works

• Kissing Kate (2003)
• The Fashion Disaster that Changed My Life (2005)
• Rhymes With Witches (2005)
• Fireworks (short story anthology)- "Such a Pretty Face" (2007)
• Prom Nights from Hell, co-written with Meg Cabot, Kim Harrison, Michele Jaffe, and Stephenie Meyer (2007)
• How to Be Bad, co-written with Sarah Mlynowski and E. Lockhart (2008)
• Bliss (2008)
• Let It Snow, co-written with Maureen Johnson and John Green (2008)
• Peace, Love, and Baby Ducks (2009)
• Luv Ya Bunches (2009)