Quaglia has held a variety of jobs, among them photographer, owner and barman of a pub, internet entrepreneur and politician. From the beginning of 1995 to the end of 1997 he was a Councilor in Genova. Since 1989, he has been active in science fiction fandom, and since 2002 he has been vice-chairman of the European Science Fiction Society, the organization which coordinates the annual Eurocon science fiction convention.

In 1994 he became friends with American science fiction writer Robert Sheckley. In 1999 he and Sheckley traveled together around Europe for over a month, the first of a number of long journeys they took together. Some of Quaglia's videos and photographs of these trips can be found on the Internet. In 2004, Quaglia and Sheckley began planning to write two books together, a project which became public a few months before Sheckley's death, in an article published by the Ukrainian press during Sheckley's last journey, a tour of the Ukraine together with Quaglia. Sheckley's death put an end to this project.

In 2003, Quaglia and British writer Ian Watson met and became friends, which led to a literary collaboration. Together they wrote the collection of My Beloved stories, some of which are available on the Internet, having been published by Helix , Flurb and in the United States, Clarkesworld Magazine . Other stories have been published in the American magazine Weird Tales, the Canadian anthology Lust For Life, New Writings in the Fantastic, the Mammoth Book of Best New Erotica volume 7 and in a other books. In 2009 these stories were collected into an anthology, The Beloved of My Beloved, published by NewCon Press, and launched in March-April 2009 at the Eurocon in Fiuggi and the Eastercon in Bradford.

Novels

• 1994: Vagabondul interspa?ial ("The Vagabond of Ether"). Nemira. ISBN 973-569-30-6
• 2002: Bread, Butter and Paradoxine. Solid. ISBN 9788873600152
• 2009: Paradoxine: The Adventures of James Vagabond (revised edition of Bread, Butter and Paradoxine). Immanion Press. ISBN 1904853676, ISBN 978-1904853671

Other fiction

• 1992: Somebody up there is lusting for me – science fiction play (distributed as a free gift to all attenders of Eurocon 1993 in Jersey)
• 1998: God Ltd (Italian: "Dio S.r.l.") – short stories collection, Nemira.
• 2006: with Ian Watson: The Beloved of My Beloved – short stories collection, NewconPress. ISBN 978-0-9555791-8-9 (hardcover), ISBN 978-0-9555791-8-6 (paperback)

Non-fiction

• 1995: The future of science fiction – essay (in the official Souvenir Book of Intersection, the 53rd World Science Fiction Convention, Glasgow)
• 2003: Pensiero stocastico ("Stochastic Thought") – essay collection Delos Books
• 2004: Gandirea Stocastica Nemira
• 2003: "Tutto quello che avreste sempre voluto sapere sull'11 settembre 2001, ma che non avete mai osato chiedervi" ("Everything you wanted to know about September 11, but have never dared to ask yourself") – essay, in Tutto quello che sai è falso. Manuale dei segreti e delle bugie. NuoviMondiMedia. ISBN 978-88-89091-50-0 (Italian edition of Everything You Know Is Wrong Russ Kick, ed.)
• 2006: Il Mito dell'11 Settembre e l'Opzione Dottor Stranamore ("The September 11th Myth and the Doctor Strangelove Option"). PonSinMor. ISBN 978-88-902775-1-1
• 2009: 11 Septembrie, Mitul. Editura Stefan. ISBN 978-973-118-120-2